Dodecyl-isopropyl-methylamin | 30427-42-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Dodecyl-isopropyl-methylamin
• 英文别名: N-methyl-N-propan-2-yldodecan-1-amine
• CAS: 30427-42-0
• 化学式: C₁₆H₃₅N
• 分子量: 241.461
• InChiKey: YGSXMSPMCKDXIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Dodecyl-isopropyl-dimethyl-ammonium; iodide 在 丙烷-1-硫醇 、 lithium hydride 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 Dodecyl-isopropyl-methylamin
  参考文献：
  名称：

  Selective demethylation of quaternary salts with lithium propylmercaptide in hexamethylphosphoramide

  摘要：

  DOI：

  10.1021/jo00950a043

文献信息

• Gene delivery carrier
  申请人：Massachusetts Institute of Technology

  公开号：US11041069B2

  公开（公告）日：2021-06-22

  Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

  本文公开了制备和利用聚（β-氨基酯）（PBAE）聚合物的方法、组合物、试剂、系统和试剂盒，这些聚合物是通过本文公开的二丙烯酸酯和胺的迈克尔加成反应合成的。不同的实施例利用内酯和内酯衍生物生成二丙烯酸酯化合物。事实证明，PBAE 聚合物是一种有效的可生物降解载体，可用于传递有机分子、无机分子、核酸、蛋白质、肽、多核苷酸、靶向剂、同位素标记的化合物、疫苗或免疫制剂等制剂。
• High cis-1,4 block copolymers of polybutadiene and polyisoprene
  申请人：Bridgestone Corporation

  公开号：US11230622B2

  公开（公告）日：2022-01-25

  A vulcanizable composition comprising rubber component, a filler, and a curing agent, where the rubber component includes a block copolymer of polybutadiene and polyisoprene, and where the block copolymer has a cis content of at least 90%.

  一种可硫化组合物，由橡胶成分、填料和硫化剂组成，其中橡胶成分包括聚丁二烯和聚异戊二烯的嵌段共聚物，嵌段共聚物的顺式含量至少为 90%。
• HIGH CIS-1,4 BLOCK COPOLYMERS OF POLYBUTADIENE AND POLYISOPRENE
  申请人：Bridgestone Corporation

  公开号：EP3538575A1

  公开（公告）日：2019-09-18
• GENE DELIVERY CARRIER
  申请人：Massachusetts Institute of Technology

  公开号：US20190194444A1

  公开（公告）日：2019-06-27

  Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
• Functionally-Modified Oligonucleotides And Subunits Thereof
  申请人：Sarepta Therapeutics, Inc.

  公开号：US20220127613A1

  公开（公告）日：2022-04-28

  Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.