N-isobutyl-succinamide | 3026-09-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: N-isobutyl-succinamide
• 英文别名: Bernsteinsaeure-amid-isobutylamid；N-Isobutyl-succinamid；N'-(2-methylpropyl)butanediamide
• CAS: 3026-09-3
• 化学式: C₈H₁₆N₂O₂
• 分子量: 172.227
• InChiKey: URKGXKAKDXSMEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丁二酰亚胺 、 异丁胺 在 水 作用下， 生成 N-isobutyl-succinamide
  参考文献：
  名称：

  Mizuno; Hirata, 1959, vol. 11, p. 241,243

  摘要：

  DOI：

文献信息

• HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES RELATED CONDITIONS
  申请人：Haque Shamsul Tasir

  公开号：US20070238669A1

  公开（公告）日：2007-10-11

  The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified compounds that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 receptor modulators exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration. The compounds of this invention show desirable pharmacokinetic properties and desirable potency in efficacy models of diabetes.

  本发明提供了新型人类胰高血糖素样肽-1（GLP-1）受体调节剂，其生物活性类似或优于天然GLP-1肽，因此可用于治疗或预防与GLP活性相关的疾病或障碍。此外，本发明提供了新的化学修饰化合物，不仅可以刺激2型糖尿病患者的胰岛素分泌，还可以产生其他有益的胰岛素促进反应。这些合成肽GLP-1受体调节剂表现出对蛋白酶水解的稳定性增加，使它们成为口服或静脉注射理想的治疗候选药物。本发明的化合物在糖尿病疗效模型中表现出理想的药代动力学特性和理想的效力。
• Quaternary ammonium amide and/or ester salts
  申请人：The Lubrizol Corporation

  公开号：EP2514807A1

  公开（公告）日：2012-10-24

  The invention relates to quaternary ammonium amide and/or ester salts and their use as additives, including their use in fuels, such as diesel fuel. The invention particularly relates to the use of quaternary ammonium amide and/or ester salts as detergents in diesel fuels.

  本发明涉及季铵盐酰胺和/或酯盐及其作为添加剂的用途，包括在柴油等燃料中的用途。本发明尤其涉及季铵盐酰胺和/或酯盐在柴油燃料中作为清洁剂的用途。
• Friction modifiers for engine oils
  申请人：Afton Chemical Corporation

  公开号：EP2826841A1

  公开（公告）日：2015-01-21

  An engine oil comprising a major amount of comprising a major amount of a base oil and a minor amount of an additive package, wherein the additive package comprises at least one friction modifier represented by the formula: wherein R is selected from a hydrocarbyl group having 12 to 28 carbon atoms, a heteroatom containing hydrocarbyl having 12 to 32 carbon atoms, or a group represented by the formula: wherein R1 and R2 are independently selected from hydrocarbyl carbonyl moieties having 12 to 28 carbon atoms, or R1 and R2 form a hydrocarbon dicarbonyl containing ring with 12 to 32 carbon atoms, and R3 and R4 are independently selected from alkyl groups having 1 to 18 carbon atoms. Methods of using the engine oil to improve thin film and/or boundary layer friction in an engine are also provided.

  一种发动机油，其主要成分包括大量基础油和少量复合添加剂，其中复合添加剂包括至少一种由公式表示的摩擦改进剂： 其中 R 选自具有 12 至 28 个碳原子的烃基、具有 12 至 32 个碳原子的含杂原子的烃基或由式表示的基团： 其中 R1 和 R2 独立地选自具有 12 至 28 个碳原子的烃基羰基，或 R1 和 R2 形成具有 12 至 32 个碳原子的含烃二羰基环，以及 R3 和 R4 独立地选自具有 1 至 18 个碳原子的烷基。此外，还提供了使用发动机油改善发动机薄膜和/或边界层摩擦的方法。
• QUATERNARY AMMONIUM ESTER SALTS
  申请人：The Lubrizol Corporation

  公开号：EP3381998A1

  公开（公告）日：2018-10-03

  The invention relates to quaternary ammonium amide and/or ester salts and their use as additives, including their use in fuels, such as diesel fuel. The invention particularly relates to the use of quaternary ammonium amide and/or ester salts as detergents in diesel fuels.

  本发明涉及季铵盐酰胺和/或酯盐及其作为添加剂的用途，包括在柴油等燃料中的用途。本发明尤其涉及季铵盐酰胺和/或酯盐在柴油燃料中作为清洁剂的用途。
• DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：EP0821668A1

  公开（公告）日：1998-02-04