meso-N,N,N',N'-tetramethyl-1,2-di(2-chlorophenyl)-1,2-ethylenediamine | 1314018-22-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: meso-N,N,N',N'-tetramethyl-1,2-di(2-chlorophenyl)-1,2-ethylenediamine
• 英文别名: (1R,2S)-1,2-bis(2-chlorophenyl)-N,N,N',N'-tetramethylethane-1,2-diamine
• CAS: 1314018-22-8
• 化学式: C₁₈H₂₂Cl₂N₂
• 分子量: 337.292
• InChiKey: INWQVQGOGGAFED-HDICACEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 三甲基氯硅烷 、 锌 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 14.5h， 生成 meso-N,N,N',N'-tetramethyl-1,2-di(2-chlorophenyl)-1,2-ethylenediamine 、 dl-N,N,N',N'-tetramethyl-1,2-di(2-chlorophenyl)-1,2-ethylenediamine
  参考文献：
  名称：

  锌和三甲基氯硅烷对芳族N，N-缩醛的还原偶联

  摘要：

  在锌的存在下，由氯三甲基硅烷活化的芳族N，N-乙缩醛和N，O-乙缩醛的还原偶联反应顺利进行，从而以良好的收率得到了相应的二胺。

  DOI：

  10.1016/j.tetlet.2011.04.104

文献信息

• Process for the reductive amination of halogen-containing substrates
  申请人：Taminco BVBA

  公开号：US10544087B2

  公开（公告）日：2020-01-28

  Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, in the presence of hydrogen, a nitrogen-containing compound, and a catalyst, wherein the presence of the nitrogen-containing compound, expressed in a molar ratio relative to the first functional group in the organic feed substrate, at least during the reaction as long as the conversion of the organic feed substrate has not yet reached 80%, is maintained below a level of 1.3. Further disclosed is a composition of the invention comprising at least 98.0% wt of 2-chloro-benzyl-dimethylamine, at most 0.60% wt of the meso-o-Cl-BDMA dimer and at least 1 ppm wt of the (+/−)-o-Cl-BDMA dimer and any use therefor.

  本发明公开了一种在氢、含氮化合物和催化剂存在下对有机原料基质中的第一官能团进行还原胺化的工艺，该原料基质包括至少一个含有卤素原子的官能团，其中至少在反应过程中，只要有机原料基质的转化率尚未达到80%，含氮化合物的存在（相对于有机原料基质中第一官能团的摩尔比）保持在1.3以下。进一步公开的是本发明的一种组合物，该组合物包含至少 98.0% wt 的 2-氯-苄基二甲胺、最多 0.60% wt 的介-O-Cl-BDMA 二聚体和至少 1ppm wt 的 (+/-)-o-Cl-BDMA 二聚体及其任何用途。
• IMPROVED PROCESS FOR THE REDUCTIVE AMINATION OF HALOGEN-CONTAINING SUBSTRATES
  申请人：Taminco bvba

  公开号：EP3374344A1

  公开（公告）日：2018-09-19
• PROCESS FOR THE REDUCTIVE AMINATION OF HALOGEN-CONTAINING SUBSTRATES
  申请人：Taminco BVBA

  公开号：US20170129847A1

  公开（公告）日：2017-05-11

  Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, in the presence of hydrogen, a nitrogen-containing compound, and a catalyst, wherein the presence of the nitrogen-containing compound, expressed in a molar ratio relative to the first functional group in the organic feed substrate, at least during the reaction as long as the conversion of the organic feed substrate has not yet reached 80%, is maintained below a level of 1.3. Further disclosed is a composition of the invention comprising at least 98.0% wt of 2-chloro-benzyl-dimethylamine, at most 0.60% wt of the meso-o-Cl-BDMA dimer and at least 1 ppm wt of the (+/−)-o-Cl-BDMA dimer and any use therefor.
• [EN] IMPROVED PROCESS FOR THE REDUCTIVE AMINATION OF HALOGEN-CONTAINING SUBSTRATES<br/>[FR] PROCÉDÉ D'AMINATION RÉDUCTRICE AMÉLIORÉ DE SUBSTRATS HALOGÉNÉS
  申请人：TAMINCO BVBA

  公开号：WO2017081546A1

  公开（公告）日：2017-05-18

  Disclosed is a process for performing a reductive amination of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, in the presence of hydrogen, a nitrogen-containing compound, and a catalyst, wherein the presence of the nitrogen-containing compound, expressed in a molar ratio relative to the first functional group in the organic feed substrate, at least during the reaction as long as the conversion of the organic feed substrate has not yet reached 80%, is maintained below a level of 1.3. Further disclosed is a composition of the invention comprising at least 98.0%wt of 2-chloro-benzyl-dimethylamine, at most 0.60%wt of the meso-o- CI-BDMA dimer and at least 1 ppm wt of the (+/-)-o-CI-BDMA dimer and any use therefor.