2-[3-((tert-butylamino)methyl)-1,4-dimethoxynaphth-2-yl]ethanol | 1037294-79-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[3-((tert-butylamino)methyl)-1,4-dimethoxynaphth-2-yl]ethanol
• 英文别名: 2-[3-[(Tert-butylamino)methyl]-1,4-dimethoxynaphthalen-2-yl]ethanol；2-[3-[(tert-butylamino)methyl]-1,4-dimethoxynaphthalen-2-yl]ethanol
• CAS: 1037294-79-3
• 化学式: C₁₉H₂₇NO₃
• 分子量: 317.428
• InChiKey: KMYREIKJMFUTDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  50.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[3-((tert-butylamino)methyl)-1,4-dimethoxynaphth-2-yl]ethanol 在 氯化亚砜 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 18.0h， 以88%的产率得到2-tert-butyl-5,10-dimethoxy-1,2,3,4-tetrahydronenz[g]isoquinoline
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014
• 作为产物：
  描述：

  ethyl (3-((tert-butylamino)methyl)-1,4-dimethoxynaphthalen-2-yl)acetate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 16.0h， 以49%的产率得到2-[3-((tert-butylamino)methyl)-1,4-dimethoxynaphth-2-yl]ethanol
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014

文献信息

• Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones
  作者：Jan Jacobs、Jurgen Deblander、Bart Kesteleyn、Kourosch Abbaspour Tehrani、Norbert De Kimpe

  DOI：10.1016/j.tet.2008.03.014

  日期：2008.5

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.