(+/-) ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-butoxypropanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: (+/-) ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-butoxypropanoate
• 英文别名: Ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-butoxypropanoate；ethyl 2-butoxy-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]propanoate
• 化学式: C₂₉H₃₃NO₅
• 分子量: 475.585
• InChiKey: SXNYHIRCUSWXPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (+/-) ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-butoxypropanoate 以69%的产率得到(+/-) 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-butoxypropanoic acid
  参考文献：
  名称：

  Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them

  摘要：

  式（1）化合物及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐或药学上可接受的溶剂，其制备方法以及使用方法。

  公开号：

  US06440961B1
• 作为产物：
  描述：

  2-(10H-Phenoxazin-10-yl)ethyl methanesulfonate 、 (S/R)-ethyl 3-(4-hydroxyphenyl)-2-butoxy-propionate 以obtained in preparation 6 by an analogous procedure to的产率得到(+/-) ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-butoxypropanoate
  参考文献：
  名称：

  Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them

  摘要：

  新型的β-芳基-α-氧基取代烷基羧酸（I）及含有它们的组合物。这些化合物具有降血脂、抗高血糖的用途。

  公开号：

  US07119198B2

文献信息

• [EN] NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES TRICYCLIQUES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CES DERNIERS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：WO1999019313A1

  公开（公告）日：1999-04-22

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.(FR) La présente invention concerne de nouveaux acides alkylcarboxyliques $g(b)-aryl-$g(a)-oxysubstitués répondant à la formule (I) et des compositions les contenant. Ces composés sont utilisés comme agents hypolipémiants et antihyperglycémiants.

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses. (中文翻译) 新型的公式（I）中的$g(b)-芳基-$g(a)-氧代取代烷基羧酸和含有它们的组合物。这些化合物具有降血脂和抗高血糖的作用。
• [EN] NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES TRICYCLIQUES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CEUX-CI ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：REDDY RESEARCH FOUNDATION

  公开号：WO2000050414A1

  公开（公告）日：2000-08-31

  The present invention relates to novel hypolipidemic, antihyperglycemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

  本发明涉及新型降脂、抗高血糖、抗肥胖和降胆固醇化合物，它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物。更具体地说，本发明涉及一般式(I)的新型β-芳基-α-氧基取代烷基羧酸及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物。
• Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Research Foundation

  公开号：US07119198B2

  公开（公告）日：2006-10-10

  Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.

  新型的β-芳基-α-氧基取代烷基羧酸（I）及含有它们的组合物。这些化合物具有降血脂、抗高血糖的用途。
• Tricyclic compounds and their use in medicine process for their
  申请人：Redd's Research Foundation

  公开号：US06054453A1

  公开（公告）日：2000-04-25

  Novel .beta.-aryl-.alpha.-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. ##STR1## The compounds have hypolipidemic, antihyperglycemic uses.

  化合物的分子式为(I)，其中芳基氧代取代的烷基羧酸(beta-aryl-alpha-oxysubstituted alkylcarboxylic acids)，以及含有这些化合物的组合物。这些化合物具有降脂和抗高血糖的作用。
• Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
  申请人：Lohray Braj Bhushan

  公开号：US06939988B1

  公开（公告）日：2005-09-06

  Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.

  化合物公式为（I）的小说β-芳基-α-氧基取代烷基羧酸及含有它们的组合物。这些化合物具有降脂，抗高血糖的用途。