Fluorescein (sodium)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Fluorescein (sodium)
• 英文别名: disodium;3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
• 化学式: C20H10Na2O5
• 分子量: 376.3
• InChiKey: RGPLGPBQJOQFJS-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.59
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  81.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Fluorescein (sodium) 、 Viscofas 以 十八氟十氢萘 为溶剂， 反应 1440.0h， 生成 fluorescein free acid
  参考文献：
  名称：

  Nonaqueous fluorinated drug delivery vehicle suspensions

  摘要：

  本发明涉及非水制药组合物，用于水生理系统中，包括悬浮在非水全氟碳或氟硅烷液体载体中的药物传递载体。悬浮的药物传递载体可以是水敏感或水稳定的，并包含治疗或诊断化合物，这些化合物在延长时间内保持稳定和药效。制药组合物具有改善的生物利用度，能够进行低剂量体积输送，并且不会将所包含的治疗或诊断化合物溶解到液体载体中，使其非常适合多剂量包装和管理。

  公开号：

  US05518731A1
• 作为产物：
  描述：

  disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate 、 藻红B 、 Erythrosin B (sodium salt) 生成 Fluorescein (sodium)
  参考文献：
  名称：

  Selective photoconductor-binder coating of absorbent surfaces

  摘要：

  用一种涂覆光电导纤维板的方法，其中光电导体、树脂和树脂的溶剂分别被选中并组合，当应用于多孔板时，它们具有不同的渗透能力，从而使光电导体具有最小渗透能力，树脂具有更大的渗透能力，溶剂具有更大的渗透能力，这些组分被选中以从板的表面向内具有逐渐增加的介电常数，树脂是疏水的，能够润湿光电导体和纤维。

  公开号：

  US04134762A1

文献信息

• [EN] 4-AMINOQUINOLINE COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS<br/>[FR] COMPOSÉS DE 4-AMINOQUINOLINE POUR LE TRAITEMENT DE L'ANGIOGENÈSE
  申请人：SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST

  公开号：WO2019173482A1

  公开（公告）日：2019-09-12

  Described herein is the use of 4-aminoquinoline compounds as inhibitors of angiogenesis, such as retinal pathological angiogensis. Also described herein are compositions and formulations comprising such compounds for the use in treatment of pathological angiogenesis.

  本文描述了4-氨基喹啉化合物作为抑制血管生成的用途，例如视网膜病理性血管生成。本文还描述了包含这些化合物的组合物和配方，用于治疗病理性血管生成。
• [EN] FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME<br/>[FR] POLYMERSOMES ET NANORÉACTEURS SENSIBLES À LA FORCE; PROCÉDÉS LES UTILISANT
  申请人：ADOLPHE MERKLE INSTITUTE UNIV OF FRIBOURG

  公开号：WO2019034597A1

  公开（公告）日：2019-02-21

  The mechanically induced melting properties of DNA were employed to achieve force labile membranes is described. Nucleobase pairs were used as mechanophores. Adenine and thymine functionalized complementary amphiphilic block copolymers were self-assembled into polymersomes. The nucleobases formed hydrogen bonds which were disrupted upon force stimulation. The exposure of the disconnected nucleobases to the hydrophobic matrix of the membranes lead to a change of permeability which permitted the exchange of water-soluble molecules throughout the polymer matrix. Moreover, the encapsulation of horseradish peroxidase enabled the reaction of luminol with hydrogen peroxide to yield a luminescence producing species similar to the marine bioluminescence. Moreover, the same nano-reactors were employed to catalyze the formation of a polyacrylamide gel when force was applied. Insights into the change of permeability of supramolecular networks upon force are provided. These systems are useful for drug delivery, as nanoreactors and for the selective release of curing agents for 3D printing, or fragrances.

  DNA的机械诱导熔化特性被用来实现易受力破裂的膜。核碱基对被用作机械感受器。腺嘌呤和胸腺嘧啶功能化的互补两性分块共聚物自组装成聚合体囊。核碱基形成氢键，在受力刺激下被破坏。断开的核碱基暴露在膜的疏水基质中，导致渗透性的改变，从而允许水溶性分子在聚合物基质中交换。此外，封装辣根过氧化物酶使得辣根酰胺与过氧化氢反应产生类似海洋生物发光的发光物种。此外，当施加力时，相同的纳米反应器被用来催化聚丙烯酰胺凝胶的形成。提供了关于受力下超分子网络渗透性变化的见解。这些系统可用于药物传递、纳米反应器以及用于3D打印的固化剂或香料的选择性释放。
• THIOL-BASED FLUORESCENT PROBE FOR REACTIVE SPECIES
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20200140452A1

  公开（公告）日：2020-05-07

  Detection of nitroxyl (HNO), the transient one-electron reduced form of nitric oxide, is a significant challenge owing to its high reactivity with biological thiols (rate constants as high as 10 9 M −1 s −1 ). Reported herein is a new thiol-based HNO-responsive trigger that can compete against reactive thiols for HNO. This process forms an N-hydroxysulfenamide intermediate which cyclizes to release a masked fluorophore leading to fluorescence enhancement. To ensure a rapid cyclization step, the disclosed design capitalizes on two established physical organic phenomena: the alpha-effect and the Thorpe-Ingold effect. Using this new trigger, NitroxylFluor was developed; a selective HNO-responsive fluorescent probe. Treatment of NitroxylFluor with an HNO donor results in a 16-fold turn-on. This probe also exhibits excellent selectivity over various reactive nitrogen, oxygen, and sulfur species and efficacy in the presence of thiols (e.g., glutathione in mM concentrations). Also, live cell imaging of HNO using NitroxylFluor was performed.

  氮氧化物（HNO）的检测是一个重要挑战，因为它与生物硫醇具有很高的反应性（速率常数高达10^9 M^-1s^-1）。本文报道了一种新的基于硫醇的HNO响应触发器，可以与反应性硫醇竞争HNO。这个过程形成了一种N-羟基磺酰胺中间体，它环化释放出一个掩蔽的荧光团，导致荧光增强。为了确保快速的环化步骤，所披露的设计利用了两种已建立的物理有机现象：α效应和Thorpe-Ingold效应。利用这种新的触发器，开发了NitroxylFluor；一种选择性的HNO响应荧光探针。将NitroxylFluor与HNO供体处理会导致16倍的开启。该探针还表现出对各种反应性氮、氧和硫物种的优异选择性，以及在硫醇存在的情况下（例如，以毫摩尔浓度存在的谷胱甘肽）的有效性。此外，使用NitroxylFluor进行了HNO的活细胞成像。
• [EN] NOVEL ANTI-BIOFILM AGENTS<br/>[FR] NOUVEAUX AGENTS ANTI-BIOFILMS
  申请人：YISSUM RES DEV CO

  公开号：WO2010058402A1

  公开（公告）日：2010-05-27

  Novel agents exhibiting anti-biofilm formation activity while being non-cytotoxic are provided, as well as methods of using the same, either per se or conjugated to a polymer, for preventing and/or reducing the formation of microbial biofilms and/or for disrupting microbial biofilms. The novel agents described herein include thiazolidine-2,4-diones (TZDs), pyrrolidine -2, 5- diones (PYDs), imidazolidine-2, 4 -diones or oxazolidine-2,4-diones, substituted by an alkylidene having 7-20 carbon atoms in its backbone chain.

  提供了一种表现出抗生物膜形成活性且无细胞毒性的新型药剂，以及使用这些药剂的方法，可以直接使用或与聚合物结合，用于预防和/或减少微生物生物膜的形成和/或破坏微生物生物膜。本文描述的新型药剂包括噻唑烷-2,4-二酮（TZDs）、吡咯烷-2,5-二酮（PYDs）、咪唑烷-2,4-二酮或噁唑烷-2,4-二酮，其通过具有7-20个碳原子的烷基烯链进行取代。
• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。

表征谱图