(+/-)-trans-1-Hydroxy-1,2,3,4-tetrahydro-<2>naphthoesaeure

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (+/-)-trans-1-Hydroxy-1,2,3,4-tetrahydro-<2>naphthoesaeure
• 英文别名: trans-1-Hydroxy-tetralincarbonsaeure-(2)；(+/-)-trans-1-hydroxy-1,2,3,4-tetrahydro-[2]naphthoic acid；(+/-)-trans-1-Hydroxy-1,2,3,4-tetrahydro-[2]naphthoesaeure；(1R,2S)-1-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: VXICHYRRWIXYGD-UWVGGRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮乙烷 、 (+/-)-trans-1-Hydroxy-1,2,3,4-tetrahydro-<2>naphthoesaeure 生成 trans-1-Hydroxy-1,2,3,4-tetrahydro-naphthoesaeure-(2)-ethylester
  参考文献：
  名称：

  Lukes,R. et al., Collection of Czechoslovak Chemical Communications, 1960, vol. 25, p. 492 - 501

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氧代-1,2,3,4-四氢萘-2-羧酸乙酯 在 氢氧化钾 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 (+/-)-trans-1-Hydroxy-1,2,3,4-tetrahydro-<2>naphthoesaeure
  参考文献：
  名称：

  Schoofs,A. et al., Bulletin de la Societe Chimique de France, 1976, p. 1215 - 1221

  摘要：

  DOI：

文献信息

• Clinical evaluation of meniscus repair with a bioabsorbable arrow: a 2- to 3-year follow-up study
  作者：A. Ellermann、R. Siebold、J. Buelow、C. Sobau

  DOI：10.1007/s00167-002-0301-3

  日期：2002.9

  In a clinical study with the bioabsorbable Bionx Meniscus Arrow we prospectively evaluated 113 consecutive patients (113 menisci) after all-inside meniscus repair. Repairs were performed in either the medial (80.5%) or lateral (19.5%) posterior horn in the red-red or red-white meniscal zone; 66% of patients underwent concomitant ACL reconstruction. Assessment was based on history, clinical examination, and Lysholm [37] and Cincinnati Knee Scores. After a mean follow-up was 33 months (range 24-43; n=105) 21 (20%) patients showed signs and symptoms consistent with a meniscus tear (16 medial, 5 lateral) and underwent partial meniscectomy. In 11 (52%) of the revised patients concomitant ACL reconstruction was performed; 4 (19%) of revised patients were older than 35 years. In the nonrevised the average Lysholm Score was 92.5 and the average Cincinnati Score 90.4. Two patients showed a distinct femoral cartilage damage. Patient's age did not significantly affect the revision rate. Meniscus repair with the bioabsorbable arrow leads to clinical results comparable to those of traditional suture techniques. When stabilized, patients with concomitant ACL reconstruction showed comparable results to patients without ACL rupture. The simple and time saving all-inside insertion obviates the need for additional incisions and avoids knot tying. A proper tear selection and arrow positioning is necessary and should avoid cartilage damage.