N-(2-fluorophenyl)-4-piperidinamine | 886507-17-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-fluorophenyl)-4-piperidinamine
• 英文别名: N-(2-fluorophenyl)piperidin-4-amine；4-[(2-fluorophenyl)amino]piperidine
• CAS: 886507-17-1
• 化学式: C₁₁H₁₅FN₂
• mdl: MFCD06740640
• 分子量: 194.252
• InChiKey: QPTMDHYTCLTFRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Boc-4-(2-氟苯氨基)-哌啶 、 N-(3-氟苯基)哌啶-4-胺 生成 N-(2-fluorophenyl)-4-piperidinamine
  参考文献：
  名称：

  BENZYLPIPERAZINE DERIVATIVES AS MOTILIN RECEPTOR ANTAGONISTS

  摘要：

  本发明涉及公式（I）的化合物：其制备过程，包含它们的制药组合物以及它们在治疗通过GPR38受体介导的疾病或疾病中的应用。

  公开号：

  US20110275815A1

文献信息

• Piperazine Heteroaryl Derivatives as Gpr38 Agonists
  申请人：MacDonald Gregor James

  公开号：US20080312209A1

  公开（公告）日：2008-12-18

  The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Z, X and B are as defined in the specification. The compounds are partial or full agonists at the GPR38 receptor. Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.

  该发明提供了式（I）的化合物或其药学上可接受的盐， 其中R1、R2、R3、R4、R5、R6、Z、X和B如规范中所定义。这些化合物是GPR38受体的部分或全激动剂。还提供了包括这些化合物的药物组合物、制备这些化合物的方法、这些化合物的用途以及涉及这些化合物的方法。
• ACETYLENE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS
  申请人：Thomas Abraham

  公开号：US20080182851A1

  公开（公告）日：2008-07-31

  The present invention provides Stearoyl CoA Desaturase (SCD) inhibitors. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase 1 (SCD1) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase (SCD) inhibitors.

  本发明提供了硬脂酰辅酶A脱饱和酶（SCD）抑制剂。特别地，本文描述的化合物对于治疗或预防由硬脂酰辅酶A脱饱和酶1（SCD1）抑制剂调节的疾病、症状和/或疾病具有用处。本文还提供了制备上述化合物的过程、用于其合成的中间体、其制药组合物以及治疗或预防由硬脂酰辅酶A脱饱和酶（SCD）抑制剂调节的疾病、症状和/或疾病的方法。
• Biaryl Compounds Useful as Agonists of the Gpr38 Receptor
  申请人：MacDonald Gregor James

  公开号：US20080306083A1

  公开（公告）日：2008-12-11

  The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.

  本发明涉及新型联苯衍生物，例如式（I）化合物，其具有作为GPR38受体激动剂的活性，以及在治疗胃肠道疾病中使用这种化合物或其制剂的药物组合物。
• Benzylpiperazine derivatives as motilin receptor agonists
  申请人：Glaxo Group Limited

  公开号：US08012981B2

  公开（公告）日：2011-09-06

  The invention relates to compounds of formula (I): processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

  本发明涉及公式(I)的化合物，其制备方法，含有它们的制药组合物以及它们在通过GPR38受体介导的疾病或疾病的治疗中的使用。
• Process for preparing piper azine derivatives
  申请人：Glaxo Group Limited

  公开号：US08236953B2

  公开（公告）日：2012-08-07

  The invention relates to compounds of formula (I): processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

  本发明涉及式(I)的化合物，其制备过程，含有它们的药物组合物以及它们在通过GPR38受体介导的疾病或疾病治疗中的应用。