8-Nitro-7-hydroxy-4-oxochromen-2-carbonsaeureethylester | 30192-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-Nitro-7-hydroxy-4-oxochromen-2-carbonsaeureethylester
• 英文别名: 7-hydroxy-8-nitro-4-oxo-4H-chromene-2-carboxylic acid ethyl ester；ethyl 7-hydroxy-8-nitro-4-oxochromen-2-carboxylate；4H-1-Benzopyran-2-carboxylic acid, 7-hydroxy-8-nitro-4-oxo-, ethyl ester；ethyl 7-hydroxy-8-nitro-4-oxochromene-2-carboxylate
• CAS: 30192-14-4
• 化学式: C₁₂H₉NO₇
• 分子量: 279.206
• InChiKey: XNPCFJMLTDVSRG-UHFFFAOYSA-N

物化性质

• 沸点：
  441.2±45.0 °C(Predicted)
• 密度：
  1.555±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  8-Nitro-7-hydroxy-4-oxochromen-2-carbonsaeureethylester 在 palladium on activated charcoal 盐酸 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙醇 、 邻二氯苯 为溶剂， 反应 13.0h， 生成 Ethyl-2-trifluoromethyl-3,6,7,8-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalene-8-carboxylate
  参考文献：
  名称：

  New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D2 Template

  摘要：

  Based on the 7-OH-2-(aminomethyl)chroman dopamine D-2 template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4). (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00778-8

文献信息

• 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA[A]-NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY
  申请人：wyeth

  公开号：US20030037701A1

  公开（公告）日：2003-02-27

  Compounds of the Formula (I): 1 are useful in the treatment of disorders associated with brain dopamine dysregulation.

  公式为(I)的化合物1可用于治疗与大脑多巴胺失调相关的疾病。
• 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
  申请人：Wyeth

  公开号：US06541501B2

  公开（公告）日：2003-04-01

  Compounds of the Formula (I): are useful in the treatment of disorders associated with brain dopamine dysregulation.

  公式（I）的化合物在治疗与大脑多巴胺失调相关的疾病方面非常有用。
• 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA A]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY
  申请人：Wyeth

  公开号：EP1409490A1

  公开（公告）日：2004-04-21
• 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA A|NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY
  申请人：Wyeth

  公开号：EP1409490B1

  公开（公告）日：2006-09-06
• 2-(AMINOMETHYL)-TETRAHYDRO-9-OXA-1,3-DIAZA-CYCLOPENTA a]NAPHTHALENYL DERIVATIVES WITH ANTIPSYCHOTIC ACTIVITY
  申请人：Wyeth

  公开号：EP1421086A1

  公开（公告）日：2004-05-26