N(4-pyridylmethylene)diphenylethanedione monohydrazone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N(4-pyridylmethylene)diphenylethanedione monohydrazone
• 英文别名: 1,2-Diphenyl-2-(pyridin-4-ylmethylidenehydrazinylidene)ethanone
• 化学式: C₂₀H₁₅N₃O
• 分子量: 313.359
• InChiKey: FVZGGWJAIUCNID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N(4-pyridylmethylene)diphenylethanedione monohydrazone 、 silver perchlorate 以 甲醇 为溶剂， 反应 168.0h， 以60%的产率得到[Ag(N(4-pyridylmethylene)diphenylethanedione monohydrazone)₂]ClO₄
  参考文献：
  名称：

  Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base

  摘要：

  An N3O Schiff base (L), 1 : 1 condensate of benzil monohydrazone and 4-pyridine carboxaldehyde, and its Zn(II), Cd(II), and Ag(I) complexes were synthesized and characterized by elemental analyses and various spectroscopic techniques. The crystal structures of [ZnL2Br2] (1), [CdL2I2]center dot CH2Cl2, (2)center dot CH2Cl2, and [Ag(L)(2)]ClO4 (3) have been determined using X-ray crystallography. The Zn(II) and Cd(II) complexes show a tetrahedral configuration whereas in the asymmetric unit of 3, two independent coordination units of Ag(I) are present. Carbonyl-silver interaction, weak C-HMIDLINE HORIZONTAL ELLIPSISO interaction, and also pi-pi interaction are present in 3 in the solid state. The synthesized complexes have antibacterial activity against Klebsiella pneumoniae 114, Escherichia coli K88, Salmonella typhi ATCC 34, Bacillus subtilis UC564, and Staphylococcus aureus ATCC25923. The results showed that in some cases the antibacterial activities of the complexes were comparable to standard antibiotics Tetracycline and Streptomycin. The antifungal activities of the complexes were also studied for Aspergillus niger, Aspergillus oryzae, Penicillium notatum, and Saccharomyces cerevisiae. MIC values of 1, 2 center dot CH2Cl2, and 3 are less than the Nystatin standard.

  DOI：

  10.1080/00958972.2014.951346
• 作为产物：
  描述：

  4-吡啶甲醛 、 苯偶酰腙 以 甲醇 为溶剂， 反应 8.0h， 以75%的产率得到N(4-pyridylmethylene)diphenylethanedione monohydrazone
  参考文献：
  名称：

  Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base

  摘要：

  An N3O Schiff base (L), 1 : 1 condensate of benzil monohydrazone and 4-pyridine carboxaldehyde, and its Zn(II), Cd(II), and Ag(I) complexes were synthesized and characterized by elemental analyses and various spectroscopic techniques. The crystal structures of [ZnL2Br2] (1), [CdL2I2]center dot CH2Cl2, (2)center dot CH2Cl2, and [Ag(L)(2)]ClO4 (3) have been determined using X-ray crystallography. The Zn(II) and Cd(II) complexes show a tetrahedral configuration whereas in the asymmetric unit of 3, two independent coordination units of Ag(I) are present. Carbonyl-silver interaction, weak C-HMIDLINE HORIZONTAL ELLIPSISO interaction, and also pi-pi interaction are present in 3 in the solid state. The synthesized complexes have antibacterial activity against Klebsiella pneumoniae 114, Escherichia coli K88, Salmonella typhi ATCC 34, Bacillus subtilis UC564, and Staphylococcus aureus ATCC25923. The results showed that in some cases the antibacterial activities of the complexes were comparable to standard antibiotics Tetracycline and Streptomycin. The antifungal activities of the complexes were also studied for Aspergillus niger, Aspergillus oryzae, Penicillium notatum, and Saccharomyces cerevisiae. MIC values of 1, 2 center dot CH2Cl2, and 3 are less than the Nystatin standard.

  DOI：

  10.1080/00958972.2014.951346