4-pentyltetrahydro-2H-thiopyran-1,1-dioxide | 65865-33-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: 4-pentyltetrahydro-2H-thiopyran-1,1-dioxide
• 英文别名: 4-Pentyl-pentamethylensulfon；4-pentyl-tetrahydro-thiopyran 1,1-dioxide；4-n-Pentylthiane, S,S-dioxide；4-pentylthiane 1,1-dioxide
• CAS: 65865-33-0
• 化学式: C₁₀H₂₀O₂S
• 分子量: 204.334
• InChiKey: UOSSYAXINWRLSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-戊基硫烷 生成 4-pentyltetrahydro-2H-thiopyran-1,1-dioxide
  参考文献：
  名称：

  KRIVONOGOV V. P.; DRONOV V. I.; NIGMATULLINA R. F., XIMIYA GETEROTSIKL. SOEDIN., 1977, HO 12, 1622-1624

  摘要：

  DOI：

文献信息

• Aromatic sulfide/sulfone polymer production
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0309955A1

  公开（公告）日：1989-04-05

  A process is provided for the production of aromatic sulfide/sulfone polymers which comprises contacting under suitable polymerization reaction conditions: (1) at least one dihaloaromatic sulfone, (2) water, and (3) a complex comprising at least one alkali metal hydrosulfide.

  提供了一种生产芳香族硫化物/砜聚合物的工艺，该工艺包括在合适的聚合反应条件 下：(1) 至少一种二卤代芳香族砜；(2) 水；(3) 由至少一种碱金属硫氢化物组成的络合物。
• Isoxazolyl substituted imidazopyridines
  申请人：CELLCENTRIC LTD

  公开号：US10428065B2

  公开（公告）日：2019-10-01

  A compound which is an isoxazolyl imidazopyridine of formula (I): wherein: R0 and R, which are the same or different, are each H or C alkyl; R9′ and R9″, which are the same or different, are each H or F; X is -(alk)n-, -alk-C(═O)—NR—, -alk-NR—C(═O)— or -alk-C(═O)—; R1 is selected from —S(═O)2R′ and a 4- to 7-membered heterocyclic group which is unsubstituted or substituted; R2 and R2′, which are the same or different, are each H or C1-6 alkyl; or R2 and R2′ form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3′, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R′ is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer.

  一种化合物，它是式(I)的异噁唑基咪唑吡啶： 其中：R0和R相同或不同，各自为H或C烷基；R9′和R9″相同或不同，各自为H或F；X为-(alk)n-、-alk-C(═O)-NR-、-alk-NR-C(═O)-或-alk-C(═O)-；R1 选自-S(═O)2R′和未取代或取代的 4 至 7 元杂环基团； R2 和 R2′相同或不同，各自为 H 或 C1-6 烷基；R3和R3′相同或不同，各自为H、C1-6烷基、OH或F；R4为苯基或5-12元含N杂芳基且未取代或取代；alk为C1-6亚烷基；R′为C1-6烷基；n为0或1；或其药学上可接受的盐。该化合物具有调节 p300 和/或 CBP 活性的活性，可用于治疗癌症。
• VOLYNSKIJ N. P.; SHCHERBAKOVA L. P., IZV. AN CCCP. CEP. XIM., 1979, HO 5, 1077-1080
  作者：VOLYNSKIJ N. P.、 SHCHERBAKOVA L. P.

  DOI：——

  日期：——
• US4125525A
  申请人：——

  公开号：US4125525A

  公开（公告）日：1978-11-14
• US5015725A
  申请人：——

  公开号：US5015725A

  公开（公告）日：1991-05-14