n-pentadecylammonium chloride | 1838-05-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: n-pentadecylammonium chloride
• 英文别名: pentadecylammonium chloride；Tetra-n-pentadecylammonium；pentadecylamine; hydrochloride；hydron;pentadecan-1-amine;chloride
• CAS: 1838-05-7
• 化学式: C₁₅H₃₃N*ClH
• 分子量: 263.895
• InChiKey: JRCNNGRDCFZVPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.46
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  potassium permanganate 、 n-pentadecylammonium chloride 生成 oxygen(2-);pentadecan-1-amine;hydrochloride
  参考文献：
  名称：

  IVANOVA, G. I.;PURTOV, A. I., XIMIYA I TEXNOL. VODY, 12,(1990) N, S. 522-523

  摘要：

  DOI：

文献信息

• Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors
  作者：Nejc Petek、Bogdan Štefane、Marko Novinec、Jurij Svete

  DOI：10.1016/j.bioorg.2018.11.029

  日期：2019.3

  novel 7-aminoalkyl substituted pyrazolo[1,5-a]pyrimidine derivatives were synthesized and tested for inhibition of cathepsin K. The synthetic methodology comprises cyclization of 5-aminopyrazoles with N-Boc-α-amino acid-derived ynones followed by transformation of the ester and the Boc-amino functions. It allows for easy diversification of the pyrazolo[1,5-a]pyrimidine scaffold at various positions

  合成了一系列新颖的7-氨基烷基取代的吡唑并[1,5-a]嘧啶衍生物，并测试了其对组织蛋白酶K的抑制作用。合成方法包括用N-Boc-α-氨基酸衍生的炔酮环化5-氨基吡唑通过酯和Boc-氨基官能团的转化。它使得吡唑并[1，5-a]嘧啶支架易于在各种位置上多样化。还进行了与吡唑并[1,5-a]嘧啶衍生物的分子对接研究，以阐明组织蛋白酶K活性位点的结合模式。合成的化合物表现出中等的抑制活性（Ki≥77μM）。
• [EN] HIGH-CAPACITY OPTICAL STORAGE MEDIA<br/>[FR] SUPPORTS DE MÉMOIRE OPTIQUE À GRANDE CAPACITÉ
  申请人：CIBA SC HOLDING AG

  公开号：WO2006018352A1

  公开（公告）日：2006-02-23

  The invention accordingly relates to an optical recording medium comprising a substrate, a reflecting layer and a recording layer, wherein the recording layer comprises a compound of formula (I) or a mesomeric or tautomeric form thereof, wherein M1 is a metal cation in the oxidation state +3, a hydroxy or halogeno metal group wherein the metal is in the oxidation state +4, or an oxo metal group wherein the metal is in the oxidation state +5; (III) and (IV) are each independently of the other (V), (VI) or (VII); (VIII) is (IX), (X), (XI), (XII), (XIII) or (XIV); (XV) is (XVI) or C2-C8 heteroaryl unsubstituted or mono- or poly-substituted by R10, R11, R12 and/or R13; Q1 is N or CR18 , Q2 is N or CR19 , Q3, Q5 and Q7 are each independently of the other CR 20 R 21, O, S or NR22 , Q4 is CR16 or N and Q6 is CR 17 or N ; and R2 and/or R 6 are O, S or NR 33. Please see the disclosure for the other substituents which are less relevant. The compounds of formula (I) are novel and also claimed, as well as the compound of formula (II), or a mesomer or tautomer thereof, wherein R38 is halogen, CF3, NO2, CN, COR22, COOR23 , SO3R23, NCO or SCN, G1, G 2, M1, R1, R2, R4, R5, R6, R8, R22 and R23 are as defined in formula (I), M 2m+ is a cation with m positive charges, and m is an integer 1, 2 or 3. The optical recording media are remarkably suitable for DVD±R (658 nm), especially at high recording speeds.

  该发明涉及一种光学记录介质，包括基板、反射层和记录层，其中所述记录层包括式(I)的化合物或其互变异构体或互变构异体，其中M1是+3氧化态的金属阳离子，氢氧基或卤金属基，其中金属处于+4氧化态，或氧金属基，其中金属处于+5氧化态；(III)和(IV)各自独立于其他(V)、(VI)或(VII)；(VIII)是(IX)、(X)、(XI)、(XII)、(XIII)或(XIV)；(XV)是( XVI)或未经R10、R11、R12和/或R13取代的C2-C8杂环芳基；Q1是N或CR18，Q2是N或CR19，Q3、Q5和Q7各自独立于其他CR20R21、O、S或NR22，Q4是CR16或N，Q6是CR17或N；而R2和/或R6是O、S或NR33。请参阅其他不太相关的取代基的披露。式(I)的化合物是新颖的，并且也被要求，以及式(II)的化合物，或其互变异构体或互变构异体，其中R38是卤素、CF3、NO2、CN、COR22、COOR23、SO3R23、NCO或SCN，G1、G2、M1、R1、R2、R4、R5、R6、R8、R22和R23如式(I)中定义，M2m+是具有m正电荷的阳离子，m是整数1、2或3。这些光学记录介质非常适用于DVD±R（658纳米），尤其在高速记录时。
• [EN] HIGH-PERFORMANCE OPTICAL STORAGE MEDIA<br/>[FR] SUPPORT D'ENREGISTREMENT OPTIQUE A PERFORMANCE ELEVEE
  申请人：CIBA SC HOLDING AG

  公开号：WO2005090362A1

  公开（公告）日：2005-09-29

  The invention relates to an optical recording medium comprising a substrate, a reflecting layer and a recording layer, wherein the recording layer comprises a compound of formula (I), or a mesomeric or tautomeric form thereof, wherein Zn+ is a proton or an n-valent ammonium, phosphonium, metal complex or alkali metal cation and n is a number (1), (2) or (3); it being possible, where appropriate, for Zn+ to be linked to R1, R2, R3 or R4 by a direct bond or by way of an O, S or NR8 bridge. R1, to R7 are hydrogen or hydrocarbon radicals defined in the description and claims; R2 and R6 can additionally be halogen or nitro. Novel compounds of formula (I) are also claimed, these being compounds in which Zn+ is a phosphonium, metal complex or alkali metal cation or which are asymmetrical.

  本发明涉及一种光学记录介质，包括基板、反射层和记录层，其中所述记录层包括式(I)的化合物或其互变异构体或互变异构体，其中Zn+是质子或n价的铵、膦、金属配合物或碱金属阳离子，n为数字(1)、(2)或(3)；在适当的情况下，Zn+可以通过直接键或通过O、S或NR8桥连接到R1、R2、R3或R4。R1到R7是在说明和权利要求中定义的氢或碳氢基团；R2和R6还可以是卤素或硝基。还要求新的式(I)化合物，其中Zn+是膦、金属配合物或碱金属阳离子，或者是不对称的化合物。
• Olefin polymerisation catalysts and processes for producing olefin polymers
  申请人：TOSOH CORPORATION

  公开号：EP0849292A1

  公开（公告）日：1998-06-24

  Catalysts for olefin polymerization which consist essentially of a transition metal compound, a modified clay compound and an organic aluminum compound, wherein the modified clay compound comprises a reaction product of a clay mineral and a proton acid salt of a specific amine compound, as well as a method of polymerizing olefins using such catalysts. It is possible thereby to obtain olefin polymers with high productivity and low ash content.

  烯烃聚合催化剂，主要由过渡金属化合物、改性粘土化合物和有机铝化合物组成，其中改性粘土化合物包括粘土矿物和特定胺化合物的质子酸盐的反应产物，以及使用这种催化剂聚合烯烃的方法。由此可以获得生产率高、灰分含量低的烯烃聚合物。
• Ammonium ionophore
  申请人：——

  公开号：US20030159948A1

  公开（公告）日：2003-08-28

  An ammonium selective ionophore for use in ion selective electrodes.

  一种用于离子选择性电极的铵选择性离子载体。