(2S,4R,8S,12S)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (2S,4R,8S,12S)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
• 化学式: C₂₄H₃₂O₆
• 分子量: 416.5
• InChiKey: WBGKWQHBNHJJPZ-YWZQBGSISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  异丁酸酐 、 (2S,4R,8S,12S)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one 以99.7的产率得到desonide 21-isobutyrate
  参考文献：
  名称：

  Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation

  摘要：

  本发明涉及一种制备16,17-[(环己基甲基)双(氧)]-11,21-双羟基孕酮-1,4-烯-3,20-二酮[11β,16α(R)]及类似化合物的方法，通过将适当的16,17-羰基内醚与环己醛反应制备而成。

  公开号：

  US07468433B2

文献信息

• Process for the preparation of ciclesonide
  申请人：Rossetto Pierluigi

  公开号：US20070135398A1

  公开（公告）日：2007-06-14

  Provided is a process for increasing the 22R/22S epidemic ratio of ciclesonide.

  提供了一种增加环仑索尼德的22R/22S流行比的过程。
• [EN] PROCESS FOR THE PRODUCTION OF 16,17-[(CYCLOHEXYLMETHYLEN)BIS(OXY)]-11,21-DIHYDROXY-PREGNA-1,4-DIEN-3,20-DION OR ITS 21-ISOBUTYRAT BY TRANSKETALISATION<br/>[FR] PROCEDE DE PRODUCTION DU 16,17-[(CYCLOHEXYLMETHYLENE)BIS(OXY)]-11,21-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIOE OU SON 21-ISOBUTYRATE PAR TRANSCETALISATION
  申请人：BYK GULDEN LOMBERG CHEM FAB

  公开号：WO2002038584A1

  公开（公告）日：2002-05-16

  The invention relates to a process for the preparation of 16,17-[(cyclohexylmethylene)bis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione[11β,16α(R)] and similar compounds, by reaction of an appropri-ate 16,17-ketal with cyclohexanealdehyde.

  本发明涉及一种制备16,17-[(环己基亚甲基)双(氧)]-11,21-双羟基孕-1,4-二烯-3,20-二酮[11β,16α(R)]及类似化合物的方法，通过将适当的16,17-环缩酮与环己醛反应制备。
• Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
  申请人：Nycomed GmbH

  公开号：US07468433B2

  公开（公告）日：2008-12-23

  The invention relates to a process for the preparation of 16,17-[(cyclohexylmethylene)bis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione[11β,16α(R)] and similar compounds, by reaction of an appropriate 16,17-ketal with cyclohexanealdehyde.

  本发明涉及一种制备16,17-[(环己基甲基)双(氧)]-11,21-双羟基孕酮-1,4-烯-3,20-二酮[11β,16α(R)]及类似化合物的方法，通过将适当的16,17-羰基内醚与环己醛反应制备而成。
• WO2007056181A2
  申请人：——

  公开号：——

  公开（公告）日：——
• SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS
  申请人：Thommes Markus

  公开号：US20100222311A1

  公开（公告）日：2010-09-02

  Described herein are formulations of active pharmaceutical ingredients, where the active pharmaceutical ingredients or drugs are included in a solid suspension with one or more solid additives. The formulations described herein are useful for formulating any drug or active pharmaceutical ingredient, including those that have limited solubility in organic and/or aqueous solvent systems.