(+/-)-N-n-propylnoradrenaline | 7376-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (+/-)-N-n-propylnoradrenaline
• 英文别名: 1-(3,4-dihydroxy-phenyl)-2-propylamino-ethanol；4-(1-Hydroxy-2-propylamino-aethyl)-brenzcatechin；1-(3,4-Dihydroxy-phenyl)-2-propylamino-aethanol；3,4-Dihydroxy-alpha-((propylamino)methyl)benzyl alcohol；4-[1-hydroxy-2-(propylamino)ethyl]benzene-1,2-diol
• CAS: 7376-69-4
• 化学式: C₁₁H₁₇NO₃
• 分子量: 211.261
• InChiKey: FJPVLTFQDJDLPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 水 、 钯 作用下， 生成 (+/-)-N-n-propylnoradrenaline
  参考文献：
  名称：

  Preparation of N-Substituted 1-(3′,4′-Dihydroxyphenyl)-2-aminoethanols

  摘要：

  DOI：

  10.1021/ja01170a044

文献信息

• Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
  申请人：CyDex Pharmaceuticals, Inc.

  公开号：US10207008B2

  公开（公告）日：2019-02-19

  An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

  提供了一种含有 SAE-CD 和皮质类固醇的可吸入制剂。该制剂可通过任何已知的雾化器雾化给药。该制剂可包含在试剂盒中。该制剂以水溶液形式给药，但也可以干粉、即用溶液或浓缩组合物的形式储存。该制剂可用于改进的雾化系统，通过吸入给药皮质类固醇。制剂中的 SAE-CD 可显著提高布地奈德的化学稳定性。该制剂还提供了一种吸入给药方法。该制剂也可通过传统的鼻腔给药装置给药。
• NEBULIZABLE COMPOSITIONS OF QUATERNARY AMMONIUM MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：Dey L.P.

  公开号：EP2034990A2

  公开（公告）日：2009-03-18
• INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID
  申请人：CyDex Pharmaceuticals, Inc.

  公开号：US20180154015A1

  公开（公告）日：2018-06-07

  An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.
• US5047592A
  申请人：——

  公开号：US5047592A

  公开（公告）日：1991-09-10
• US6667344B2
  申请人：——

  公开号：US6667344B2

  公开（公告）日：2003-12-23