4-[4-cyano-2-[2-(1-naphthyl)propanoylamino]phenyl]butanoic acid (2-hydroxy)ethyl ester | 402473-77-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[4-cyano-2-[2-(1-naphthyl)propanoylamino]phenyl]butanoic acid (2-hydroxy)ethyl ester
• 英文别名: 2-hydroxyethyl 4-[4-cyano-2-(2-naphthalen-1-ylpropanoylamino)phenyl]butanoate
• CAS: 402473-77-2
• 化学式: C₂₆H₂₆N₂O₄
• 分子量: 430.503
• InChiKey: KJJMSOCWDNLBPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  99.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-碘乙醇 、 4-[4-cyano-2-[2-(1-naphthyl)propanoylamino]phenyl]butanoic acid 在 sodium chloride 、 potassium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 4-[4-cyano-2-[2-(1-naphthyl)propanoylamino]phenyl]butanoic acid (2-hydroxy)ethyl ester
  参考文献：
  名称：

  Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient

  摘要：

  化学式（1）1的羧酸衍生物，其中R1是COOH，COOR6等；A是烷基等；R2是烷基，烯基，炔基等；B是碳环或杂环；R4是烷基，环烷基等；R6是碳环或杂环；或其无毒盐，以其为活性成分的制备方法和含有其的药物制剂。化合物的化学式（I）可以结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，对于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症等非常有用。

  公开号：

  US20030216381A1

文献信息

• Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical aggents comprising the same as active ingredient
  申请人：Tani Kousuke

  公开号：US20050026908A1

  公开（公告）日：2005-02-03

  A carboxylic acid derivative of formula (I) wherein R 1 is COOH, COOR 6 etc.; A is alkylene etc.; R 2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R 4 is alkyl, cycloalkyl etc.; R 6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E 2 receptors, especially, EP 3 receptor and/or EP 4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.

  化合物公式（I）的羧酸衍生物，其中R1为COOH，COOR6等; A为烷基等; R2为烷基，烯基，炔基等; B为碳环或杂环; R4为烷基，环烷基等; R6为碳环或杂环; 或其非毒性盐，其制备方法以及包含其作为活性成分的制药剂。公式（I）的化合物可以结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，有助于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症。
• Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient
  申请人：Ono Pharmaceutical Co., Ltd.

  公开号：US06835752B2

  公开（公告）日：2004-12-28

  A carboxylic acid derivative of formula (1) wherein R1 is COOH, COOR6 etc.; A is alkylene etc.; R2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R4 is alkyl, cycloalkyl etc.; R6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E2 receptors, especially, EP3 receptor and/or EP4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.

  公式（1）的羧酸衍生物，其中R1为COOH，COOR6等；A为烷基等；R2为烷基，烯丙基，炔基等；B为碳环或杂环；R4为烷基，环烷基等；R6为碳环或杂环；或其无毒盐。制备该化合物的方法和以其为活性成分的药物。公式（I）化合物能够结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，有助于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症等。
• Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
  申请人：——

  公开号：US20030216381A1

  公开（公告）日：2003-11-20

  A carboxylic acid derivative of formula (1) 1 wherein R 1 is COOH, COOR 6 etc.; A is alkylene etc.; R 2 is alkyl, alkenyl, alkynyl etc.; B is carbocyclic ring or heterocyclic ring; R 4 is alkyl, cycloalkyl etc.; R 6 is carbocyclic ring or heterocyclic ring; or non-toxic salts thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same as active ingredient. The compound of the formula (I) can bind to Prostaglandin E 2 receptors, especially, EP 3 receptor and/or EP 4 receptor and show the antagonizing activity, and useful for the prevention and/or treatment of disease, for example, pain, allergy, Alzheimer's disease, cancer.

  化学式（1）1的羧酸衍生物，其中R1是COOH，COOR6等；A是烷基等；R2是烷基，烯基，炔基等；B是碳环或杂环；R4是烷基，环烷基等；R6是碳环或杂环；或其无毒盐，以其为活性成分的制备方法和含有其的药物制剂。化合物的化学式（I）可以结合到前列腺素E2受体，特别是EP3受体和/或EP4受体，并显示拮抗活性，对于预防和/或治疗疾病，例如疼痛，过敏，阿尔茨海默病，癌症等非常有用。