6-nitro-1H-1,8-naphthyridin-2-one | 1174936-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-nitro-1H-1,8-naphthyridin-2-one
• CAS: 1174936-25-4
• 化学式: C₈H₅N₃O₃
• 分子量: 191.146
• InChiKey: ZPINRBOIURLJHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-nitro-1H-1,8-naphthyridin-2-one 在 三氯氧磷 作用下， 生成 2-chloro-6-nitro-1,8-naphthyridine
  参考文献：
  名称：

  Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists

  摘要：

  A series of 2-aminobenzimidazole-based MCH1R antagonists was identified by core replacement of the aminoquinoline lead 1. Subsequent modi. cation of the 2- and 5-positions led to improvement in potency and intrinsic clearance. Compound 25 exhibited good plasma and brain exposure, and attenuated MCH induced food intake at 30 mg/kg PO in rats. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.147
• 作为产物：
  描述：

  tert-butyl 3-(2-amino-5-nitropyridin-3-yl)acrylate 在 盐酸 作用下， 以 水 为溶剂， 生成 6-nitro-1H-1,8-naphthyridin-2-one
  参考文献：
  名称：

  Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists

  摘要：

  A series of 2-aminobenzimidazole-based MCH1R antagonists was identified by core replacement of the aminoquinoline lead 1. Subsequent modi. cation of the 2- and 5-positions led to improvement in potency and intrinsic clearance. Compound 25 exhibited good plasma and brain exposure, and attenuated MCH induced food intake at 30 mg/kg PO in rats. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.147