3,4-(vinylenedioxy)thiophene | 272-72-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶英
• 英文名称: 3,4-(vinylenedioxy)thiophene
• 英文别名: Thieno[3,4-b][1,4]dioxine
• CAS: 272-72-0
• 化学式: C₆H₄O₂S
• 分子量: 140.163
• InChiKey: NUHPCCLSSNAGJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-(vinylenedioxy)thiophene 在 正丁基锂 、 copper dichloride 作用下， 以 四氢呋喃 为溶剂， 以74%的产率得到5-Thieno[3,4-b][1,4]dioxin-5-ylthieno[3,4-b][1,4]dioxine
  参考文献：
  名称：

  3,4-Vinylenedioxythiophene (VDOT): a new building block for thiophene-based π-conjugated systems

  摘要：

  本文介绍了标题化合物的合成及其在 Ï-共轭体系中作为构件的用途。

  DOI：

  10.1039/b513923f
• 作为产物：
  描述：

  3,4-二甲氧基噻吩 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) potassium tert-butylate 、 对甲苯磺酸 作用下， 以 甲苯 、 叔丁醇 为溶剂， 生成 3,4-(vinylenedioxy)thiophene
  参考文献：
  名称：

  3,4-Vinylenedioxythiophene (VDOT): a new building block for thiophene-based π-conjugated systems

  摘要：

  本文介绍了标题化合物的合成及其在 Ï-共轭体系中作为构件的用途。

  DOI：

  10.1039/b513923f

文献信息

• Dual Pharmacophores - PDE4-Muscarinic Antagonistics
  申请人：Callahan James Francis

  公开号：US20090203657A1

  公开（公告）日：2009-08-13

  The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory activity against PDE4 and muscarinic acetylcholine receptors (mAChRs), and thus being useful for treating respiratory diseases.

  本发明涉及具有式（I）的新化合物及其药用盐，药物组合物及其用作对PDE4和肌胆碱受体（mAChRs）具有抑制活性的双色素，因此可用于治疗呼吸道疾病。
• [EN] DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS<br/>[FR] PHARMACOPHORES DUALS, ANTAGONISTES DES RÉCEPTEURS MUSCARINIQUES ET INHIBITEURS DE L'ACTIVITÉ PDE4
  申请人：GLAXO GROUP LTD

  公开号：WO2009100169A1

  公开（公告）日：2009-08-13

  The present invention is directed to novel compounds of Formula's (I) - (VI), and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of and/or prophylaxis of respiratory diseases, including inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis.

  本发明涉及式(I) - (VI)的新化合物，以及其药学上可接受的盐、药物组合物及其在治疗中的应用，例如作为磷酸二酯酶IV (PDE4)的抑制剂和肌碱乙酰胆碱受体 (mAChRs)的拮抗剂，用于治疗和/或预防呼吸道疾病，包括炎症性和/或过敏性疾病，如慢性阻塞性肺病（COPD）、哮喘、鼻炎（例如过敏性鼻炎）、特应性皮炎或银屑病。
• Robust PEDOT films by covalent bonding to substrates using in tandem sol–gel, surface initiated free-radical and redox polymerization
  作者：Anand G. Sadekar、Dhairyashil Mohite、Sudhir Mulik、Naveen Chandrasekaran、Chariklia Sotiriou-Leventis、Nicholas Leventis

  DOI：10.1039/c1jm12563j

  日期：——

  Poly(3,4-ethylenedioxythiophene), PEDOT, films are used as antistatic coatings on electrically insulating substrates such as plastic and glass. A novel method for the synthesis of conducting PEDOT films on insulators relies on sol–gel chemistry to attach a di-Si(OEt)3 functionalized free radical initiator (AIBN) on oxidized surfaces, followed by: (a) attachment of 3,4-(vinylenedioxy)thiophene (VDOT: an analogue to EDOT susceptible to radical addition through its vinylenedioxy group); and, (b) oxidative (with FeCl3) co-polymerization of surface-confined VDOT with 3,4-ethylenedioxythiophene (EDOT). In conjunction with classical photolithography, the method yields thin (∼150 nm) yet dense, pinhole-free (confirmed electrochemically), hard (>6H), extremely adhesive (5B), patterned, highly conducting (52 mho cm−1) films. The process is applied mainly on glass but it works equally well on oxidized metal surfaces (aluminum, steel, Pt). Control studies related to “grafting from” with surface-confined AIBN were conducted by growing inexpensive poly(styrene) and poly(methylmethacrylate) films.

  聚（3,4-亚乙二氧基噻吩）（PEDOT）薄膜可用作塑料和玻璃等电绝缘基材上的抗静电涂层。在绝缘体上合成导电 PEDOT 薄膜的新方法是通过溶胶化学将二硅(OEt)3 官能化自由基引发剂（AIBN）附着在氧化表面上，然后进行以下步骤：(a) 附着 3,4-（乙烯二氧基）噻吩（VDOT：EDOT 的类似物，可通过其乙烯二氧基基团进行自由基加成）；以及 (b) 表面封闭的 VDOT 与 3,4-乙烯二氧基噻吩（EDOT）发生氧化（使用 FeCl3）共聚。该方法与传统的光刻技术相结合，可获得薄（150 nm）但致密、无针孔（电化学证实）、坚硬（>6H）、粘合力极强（5B）、图案化、高导电性（52 mho cmâ1）的薄膜。该工艺主要应用于玻璃，但在氧化金属表面（铝、钢、铂）上也同样有效。通过生长廉价的聚（苯乙烯）和聚（甲基丙烯酸甲酯）薄膜，进行了与表面封闭的 AIBN "接枝 "有关的控制研究。
• 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20110124636A1

  公开（公告）日：2011-05-26

  The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R 1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

  该发明涉及一种新型2-aza-bicyclo[3.1.0]己烷衍生物，其化学式为（I），其中A、B、n和R1如说明书所述，并且涉及使用这种化合物或这种化合物的药学上可接受的盐作为药物，特别是作为促进睡眠的药物。
• CONDUCTIVE POLYMER COMPOSITION, CONDUCTIVE CURED FILM, AND ORGANIC ELECTROLUMINESCENT ELEMENT
  申请人：FUJIFILM Corporation

  公开号：EP2415833A1

  公开（公告）日：2012-02-08

  Provided is a conductive polymer composition capable of forming a conductive film that is highly resistant to organic solvents and can ensure excellent durability (i.e. a long lifespan of luminance half-life) of an electroluminescent device. The conductive polymer composition includes (A) a conductive polymer, (B) a first polymer having a repeating unit represented by Formula (1) as indicated below and a repeating unit represented by Formula (II) as indicated below, or a second polymer having a repeating unit represented by Formula (I) as indicated below, a repeating unit represented by Formula (II) below and a repeating unit represented by Formula (II') as indicated below: wherein M+ represents a monovalent cation and each n independently represents an integer, and (C) a curing agent.

  本发明提供了一种导电聚合物组合物，该组合物能够形成对有机溶剂具有高耐受性的导电膜，并能确保电致发光器件具有出色的耐用性（即亮度半衰期长）。 该导电聚合物组合物包括：(A) 导电聚合物；(B) 具有如下式(1)表示的重复单元和如下式(II)表示的重复单元的第一聚合物，或具有如下式(I)表示的重复单元、如下式(II)表示的重复单元和如下式(II')表示的重复单元的第二聚合物： 其中 M+ 代表一价阳离子，每个 n 独立地代表一个整数，以及 (C) 一种固化剂。