(1S,2S)-N,N,N’,N’-四甲基-1,2-二苯基乙烷-1,2-二胺 | 91361-07-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: (1S,2S)-N,N,N’,N’-四甲基-1,2-二苯基乙烷-1,2-二胺
• 中文别名: (1S,2S)-N,N,N',N'-四甲基-1,2-二苯基乙烷-1,2-二胺
• 英文名称: (S,S)-N,N,N',N'-tetramethyl-1,2-diphenylethylenediamine
• 英文别名: (1S,2S)-N,N,N',N'-Tetramethyl-1,2-diphenylethane-1,2-diamine
• CAS: 91361-07-8
• 化学式: C₁₈H₂₄N₂
• 分子量: 268.402
• InChiKey: MYLJZKKJRGGLPH-ROUUACIJSA-N

物化性质

• 沸点：
  328.6±42.0 °C(Predicted)
• 密度：
  1.012±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  (1S,2S)-N,N,N’,N’-四甲基-1,2-二苯基乙烷-1,2-二胺 、 碘甲烷 在 碳酸氢钠 作用下， 以 甲醇 为溶剂， 生成 ((1S,2S)-2-Dimethylamino-1,2-diphenyl-ethyl)-trimethyl-ammonium; iodide
  参考文献：
  名称：

  Efficient NMR Enantiodifferentiation of Chiral Quats with BINPHAT Anion

  摘要：

  [GRAPHICS]Hexacoordinated phosphorus BINPHAT anion is an efficient NMR chiral shift agent for quaternary ammonium cations (quats) leading to large separations (DeltaDeltadelta up to 0.29 ppm) of the proton signals of the enantiomers.

  DOI：

  10.1021/ol025669k
• 作为产物：
  描述：

  聚合甲醛 、 (1S,2S)-1,2-二苯基乙二胺 在 甲酸 作用下， 以 水 为溶剂， 反应 144.0h， 以88%的产率得到(1S,2S)-N,N,N’,N’-四甲基-1,2-二苯基乙烷-1,2-二胺
  参考文献：
  名称：

  Design, Synthesis, and Application of a C₂ Symmetric Chiral Ligand for Enantioselective Conjugate Addition of Organolithium to α,β-Unsaturated Aldimine

  摘要：

  A C-2 symmetric chiral diether ligand, (1R,2R)-1,2-dimethoxy-1,2-diphenylethane was designed and synthesized on the basis of the concept of an asymmetric oxygen atom. Mediated by the chiral diether, high enantioselectivities were achieved in conjugate addition of organolithiums to naphthaldehyde imine and cyclic and acyclic alpha,beta-unsaturated aldimines. The absolute configuration of the product is predictable by the model.

  DOI：

  10.1021/jo9813181

文献信息

• Macroscopic Polarization Change of Mononuclear Valence Tautomeric Cobalt Complexes Through the Use of Enantiopure Ligand
  作者：Feng Cheng、Shuqi Wu、Wenwei Zheng、Shengqun Su、Takumi Nakanishi、Wenhuang Xu、Pritam Sadhukhan、Hibiki Sejima、Shimon Ikenaga、Kaoru Yamamoto、Kaige Gao、Shinji Kanegawa、Osamu Sato

  DOI：10.1002/chem.202202161

  日期：2022.10.21

  To realize polarization change in non-ferroelectric crystals, valence tautomeric (VT) complexes with polar crystal structure were synthesized based on our strategy, i. e. introduction of enantiopure ligand into the metal complexes exhibiting intramolecular electron transfer. The VT transition is accompanied by the change in molecular dipole moment. Because the net polarization of the polar crystal

  为了实现非铁电晶体的极化变化，基于我们的策略合成了具有极性晶体结构的价互变异构（VT）配合物，即。e. 将对映纯配体引入表现出分子内电子转移的金属配合物中。VT跃迁伴随着分子偶极矩的变化。由于极性晶体的净极化永远不会抵消，因此实现了极化切换。
• TOMOIOKA, KIYOSHI;SHINDO, MITSURU;KOGA, KENJI, J. AMER. CHEM. SOC., 111,(1989) N1, C. 8266-8268
  作者：TOMOIOKA, KIYOSHI、SHINDO, MITSURU、KOGA, KENJI

  DOI：——

  日期：——
• Efficient NMR Enantiodifferentiation of Chiral Quats with BINPHAT Anion
  作者：Jérôme Lacour、Laurent Vial、Christelle Herse

  DOI：10.1021/ol025669k

  日期：2002.4.1

  [GRAPHICS]Hexacoordinated phosphorus BINPHAT anion is an efficient NMR chiral shift agent for quaternary ammonium cations (quats) leading to large separations (DeltaDeltadelta up to 0.29 ppm) of the proton signals of the enantiomers.
• Design, Synthesis, and Application of a <i>C</i>₂ Symmetric Chiral Ligand for Enantioselective Conjugate Addition of Organolithium to α,β-Unsaturated Aldimine
  作者：Mitsuru Shindo、Kenji Koga、Kiyoshi Tomioka

  DOI：10.1021/jo9813181

  日期：1998.12.1

  A C-2 symmetric chiral diether ligand, (1R,2R)-1,2-dimethoxy-1,2-diphenylethane was designed and synthesized on the basis of the concept of an asymmetric oxygen atom. Mediated by the chiral diether, high enantioselectivities were achieved in conjugate addition of organolithiums to naphthaldehyde imine and cyclic and acyclic alpha,beta-unsaturated aldimines. The absolute configuration of the product is predictable by the model.