tert-butyl 6-({[6-methyl-2-(4-methyl-1-piperidinyl)-3-pyridinyl]carbonyl}amino)-3,4-dihydro-2(1H)-isoquinolinecarboxylate | 689166-00-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: tert-butyl 6-({[6-methyl-2-(4-methyl-1-piperidinyl)-3-pyridinyl]carbonyl}amino)-3,4-dihydro-2(1H)-isoquinolinecarboxylate
• 英文别名: tert-butyl 6-[[6-methyl-2-(4-methylpiperidin-1-yl)pyridine-3-carbonyl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxylate
• CAS: 689166-00-5
• 化学式: C₂₇H₃₆N₄O₃
• 分子量: 464.608
• InChiKey: DIWZRXZOARUBKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl 6-({[6-methyl-2-(4-methyl-1-piperidinyl)-3-pyridinyl]carbonyl}amino)-3,4-dihydro-2(1H)-isoquinolinecarboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 6-methyl-2-(4-methyl-1-piperidinyl)-N-(1,2,3,4-tetrahydro-6-isoquinolinyl)nicotinamide
  参考文献：
  名称：

  [EN] AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA
  [FR] COMPOSES AMIDE

  摘要：

  公开号：

  WO2004039795A3
• 作为产物：
  描述：

  4-甲基哌啶 、 tert-butyl 6-{[(2-chloro-6-methyl-3-pyridinyl)carbonyl]amino}-3,4-dihydro-2(1H)-isoquinolinecarboxylate 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 tert-butyl 6-({[6-methyl-2-(4-methyl-1-piperidinyl)-3-pyridinyl]carbonyl}amino)-3,4-dihydro-2(1H)-isoquinolinecarboxylate
  参考文献：
  名称：

  [EN] AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA
  [FR] COMPOSES AMIDE

  摘要：

  公开号：

  WO2004039795A3

文献信息

• Amide compounds
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：US20040133008A1

  公开（公告）日：2004-07-08

  A compound of the formula (I) 1 wherein R 1 is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR 3 R 4 ; R 2 is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A 1 ) n -(A 2 ) m -, wherein n and m are independently 0 or 1); 2 is bivalent residue derived from arene or heteroarene; and 3 is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

  化合物的式子为（I）1，其中R1为氢、低级烷基、低级烯基、卤素（低）烷基、环（低）烷基、低级烷氧基、低级烷硫基、酰基、可选取代的芳基或NR3R4；R2为氢；或芳基或杂环芳基，每个可以被取代；X为直接键或由哌嗪衍生的二价残基；Y为-(A1)n-(A2)m-，其中n和m独立地为0或1）；2为由芳烃或杂芳烃衍生的二价残基；3为由芳烃或杂芳烃衍生的二价残基，或其盐。本发明的化合物及其盐抑制载脂蛋白B（Apo B）的分泌，并可用作预防和治疗由高循环Apo B水平引起的疾病或状况的药物。
• RING FUSED PYRAZOLE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1453832A1

  公开（公告）日：2004-09-08
• [EN] RING FUSED PYRAZOLE DERIVATIVES<br/>[FR] DERIVES DE PYRAZOLE A FUSION SUR LE CYCLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003048160A1

  公开（公告）日：2003-06-12

  This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula (I) or (II): wherein Ar is optionally substituted aryl or heteroaryl, R1-R4 are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts thereof. The invention further relates to processes for preparing such compounds, to pharmaceutical compositions containing such compounds, and to their use as therapeutic agents.
• [EN] AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA<br/>[FR] COMPOSES AMIDE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004039795A3

  公开（公告）日：2005-03-24