chlorophosphoric acid-[2]naphthyl ester-phenyl ester | 872822-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: chlorophosphoric acid-[2]naphthyl ester-phenyl ester
• 英文别名: Phosphorsaeure-phenylester-β-naphthylester-chlorid；Chlorophosphorsaeure-[2]naphthylester-phenylester
• CAS: 872822-03-2
• 化学式: C₁₆H₁₂ClO₃P
• 分子量: 318.696
• InChiKey: BDPPFRHVQVHUIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.64
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  chlorophosphoric acid-[2]naphthyl ester-phenyl ester 在 sodium azide 作用下， 以 丙酮 为溶剂， 反应 10.0h， 以60%的产率得到naphthalen-2-yl phenyl phosphorazidate
  参考文献：
  名称：

  Synthesis of Phosphoramidates: A Facile Approach Based on the C–N Bond Formation via Ir-Catalyzed Direct C–H Amidation

  摘要：

  A new synthetic route to phosphoramidates by intermolecular C-H amidation is presented. Substrates with assorted directing groups were activated by an iridium-based catalyst system and reacted with a number of phosphoryl azides, executing efficient phosphoramidate synthesis via C-N bond formations.

  DOI：

  10.1021/ol502722j
• 作为产物：
  描述：

  2-萘酚 、 alkaline earth salt of/the/ methylsulfuric acid 生成 chlorophosphoric acid-[2]naphthyl ester-phenyl ester
  参考文献：
  名称：

  Nasogastric Tube Feeding in Children with Cancer: The Effect of Two Different Formulas on Weight, Body Composition, and Serum Protein Concentrations

  摘要：

  Background: Treatment of cancer cachexia partly involves the administration of adequate amounts of energy. The aim of this study was to assess the tolerance and efficacy of two equal volumes of tube feeding, one with a standard (1 kcal/mL) and one with a high energy density (1.5 kcal/mL), during the intensive phase of treatment. Methods: Nutritional status was assessed weekly, in 27 children with a solid tumor, by measuring weight, height, midupper arm circumference, biceps and triceps skinfold, and serum proteins. Tolerance was assessed by recording the occurrence of vomiting and by expressing the administered volume as a percentage of the required volume. Results: Both formulas were equally well tolerated, leading to a significantly higher energy intake in the energy‐enriched formula group. In both formula groups, all anthropometric variables increased significantly (range of mean increase, 5.2% to 25.5%; p <.05) during the first 4 weeks of intervention. Between 4 and 10 weeks, variables continued to increase significantly in the energy‐enriched group, resulting in adequate repletion, in contrast to the standard formula group. The concentration of serum proteins, low at initiation of tube feeding, returned to the normal range within 2 to 4 weeks with no significant differences between the two groups. Conclusions: The energy‐enriched formula was more effective in improving the nutritional status of children with cancer during the intensive phase of treatment than the standard formula. Intensive, protocolized administration of an energy‐enriched formula should therefore be initiated as soon as one of the criteria for initiation of tube feeding is met. (Journal of Parenteral and Enteral Nutrition 24:351–360, 2000)

  DOI：

  10.1177/0148607100024006351