4,4'-ethylene-1,1'-diphenylazide | 72695-23-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4,4'-ethylene-1,1'-diphenylazide
• 英文别名: 4,4'-Diazidodiphenyl ethane；1-azido-4-[2-(4-azidophenyl)ethyl]benzene
• CAS: 72695-23-9
• 化学式: C₁₄H₁₂N₆
• mdl: MFCD00216014
• 分子量: 264.289
• InChiKey: XWOUTRFQXXRCIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  28.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4'-ethylene-1,1'-diphenylazide 、 4-(2-hydroxyphenyl)-1-(prop-2-yn-1-yl)-1,5-benzodiazepin-2-one 在 copper(l) iodide 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.2h， 以67%的产率得到1,1'-((1,1'-(ethane-1,2-diylbis(4,1-phenylene))bis(1H-1,2,3-triazole-4,1-diyl))bis(methylene))bis(1,5-benzodiazepin-2-one)
  参考文献：
  名称：

  Design and microwave-assisted synthesis of dimers of 1,5-benzodiazepine-1,2,3-triazole hybrids bearing alkyl/aryl spacers and their biological assessment

  摘要：

  Large series of novel N-bis-1,2,3-triazolo-linked-1,5-benzodiazepin-2-ones (BZD) have been synthesized under microwave irradiation through a Cu(I)-catalyzed double 1,3-dipolar alkyne-azide coupling reaction. This process is of considerable synthetic advantages in terms of time saving and remarkable yields. The chemical structures of the isolated compounds have been elucidated on the basis of extensive spectroscopic methods including 1D & 2D NMR, IR and HRMS. All the synthesized compounds have been evaluated for their antimicrobial and antioxidant activities. In vitro antimicrobial environment, almost all of compounds have shown an interesting activity. Among the dimers of 1,5-benzodiazepine-1,2,3-triazole compounds tested, the results revealed that the potent antibacterial was recorded to compounds 3g,l for Gram-positive (within MIC = 31.25 and 125 mu g/mL), and 3h,k for Gram-negative (within MIC = 31.25 and 125 mu g/mL). Besides, the results demonstrate that compounds 3h,k have demonstrated the strongest potential against all the tested fungus (within MIC = 62.5 and 125 mu g/mL). The antioxidant evaluation indicated that most compounds exhibited a moderate to good biological activity. (C) 2019 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2019.06.018
• 作为产物：
  描述：

  4,4'-二氨基联苄 在 硫酸 、 sodium nitrite 、 sodium azide 作用下， 以 水 、 正己烷 为溶剂， 反应 1.58h， 以82.8%的产率得到4,4'-ethylene-1,1'-diphenylazide
  参考文献：
  名称：

  [EN] SURFACE FUNCTIONALISED ADHESION
  [FR] ADHERENCE FONCTIONNALISEE EN SURFACE

  摘要：

  公开号：

  WO2005028423A3

文献信息

• Radiation-sensitive composition and pattern-formation method using the same
  申请人：Hitachi, Ltd.

  公开号：EP0070198A1

  公开（公告）日：1983-01-19

  A radiation-sensitive composition comprising (i) an iodine-containing azide compound at least a part of which can be fixed substantially in a polymer by exposure to radiation and a polymer, or (ii) an azide compound, and an iodine compound at least a part of which can be fixed substantially in a polymer by exposure to a radiation and a polymer; and a said polymer substantially having compatibility with the azide compound in case (i) or the azide compound and the iodine compound in case (ii). This composition can be subjected to dry development with oxygen plasma after the exposure followed by heating, or it can be developed with an aqueous alkaline solution if the polymer is soluble therein.

  一种对辐射敏感的组合物，包括：(i) 含碘叠氮化合物，其中至少有一部分可通过辐射和聚合物的照射而基本固定在聚合物中，或 (ii) 叠氮化合物和碘化合物，其中至少有一部分可通过辐射和聚合物的照射而基本固定在聚合物中；以及所述聚合物与(i)情况下的叠氮化合物或(ii)情况下的叠氮化合物和碘化合物基本相容。这种组合物可以在曝光后用氧等离子体进行干显影，然后加热；如果聚合物可溶于碱性水溶液，也可以用碱性水溶液显影。
• Radiation-sensitive resin composition
  申请人：JAPAN SYNTHETIC RUBBER CO., LTD.

  公开号：EP0457367A1

  公开（公告）日：1991-11-21

  A radiation-sensitive resin composition comprises a solution of an alkali-soluble resin and a radiation-sensitive compound in a solvent comprising a monooxymonocarboxylic acid ester. This composition has a high storage stability (i.e., a very small amount of fine particles are formed during storage) and is suited for use as a resist for making integrated circuits.

  一种辐射敏感树脂组合物由碱溶性树脂和辐射敏感化合物在由单氧羧酸酯组成的溶剂中的溶液组成。这种组合物具有很高的贮存稳定性（即在贮存过程中形成极少量的细颗粒），适合用作制作集成电路的抗蚀剂。
• A method of applying a layer in accordance with a pattern on a substrate
  申请人：Philips Electronics N.V.

  公开号：EP0025633B1

  公开（公告）日：1983-07-27
• THIN FILM COMPOSITE MEMBRANE INCLUDING CROSSLINKED TROGER'S BASE POLYMER
  申请人：Dow Global Technologies LLC

  公开号：EP3606650A1

  公开（公告）日：2020-02-12
• US4348472A
  申请人：——

  公开号：US4348472A

  公开（公告）日：1982-09-07