6-benzo[1,3]dioxol-5-yl-1-benzyl-piperazine-2,5-dione | 1296672-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-benzo[1,3]dioxol-5-yl-1-benzyl-piperazine-2,5-dione
• 英文别名: 6-(1,3-Benzodioxol-5-yl)-1-benzylpiperazine-2,5-dione；6-(1,3-benzodioxol-5-yl)-1-benzylpiperazine-2,5-dione
• CAS: 1296672-97-3
• 化学式: C₁₈H₁₆N₂O₄
• 分子量: 324.336
• InChiKey: AHNKXTYNZFQIDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-benzo[1,3]dioxol-5-yl-1-benzyl-piperazine-2,5-dione 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以82%的产率得到6-benzo[1,3]dioxol-5-yl-1-benzyl-piperazine
  参考文献：
  名称：

  A facile and rapid synthesis of N-benzyl-2-substituted piperazines

  摘要：

  A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.011
• 作为产物：
  描述：

  ([(benzo[1,3]dioxol-5-yl-tert-butylcarbamoyl-methyl)-benzyl-carbamoyl]-methyl)-carbamic acid tert-butyl ester 在 溶剂黄146 作用下， 反应 0.17h， 以95%的产率得到6-benzo[1,3]dioxol-5-yl-1-benzyl-piperazine-2,5-dione
  参考文献：
  名称：

  A facile and rapid synthesis of N-benzyl-2-substituted piperazines

  摘要：

  A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.011

文献信息

• A facile and rapid synthesis of N-benzyl-2-substituted piperazines
  作者：Mouhamad Jida、Mohamad Soueidan、Nicolas Willand、Francine Agbossou-Niedercorn、Lydie Pelinski、Guillaume Laconde、Rebecca Deprez-Poulain、Benoit Deprez

  DOI：10.1016/j.tetlet.2011.02.011

  日期：2011.4

  A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. (c) 2011 Elsevier Ltd. All rights reserved.