Methyl 4-oxo-1-({[3-({[(2,4,6-trimethylphenyl)amino]carbonyl}amino)-2-naphthalenyl]carbonyl}amino)cyclohexanecarboxylate | 887245-70-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Methyl 4-oxo-1-({[3-({[(2,4,6-trimethylphenyl)amino]carbonyl}amino)-2-naphthalenyl]carbonyl}amino)cyclohexanecarboxylate
• 英文别名: methyl 4-oxo-1-[[3-[(2,4,6-trimethylphenyl)carbamoylamino]naphthalene-2-carbonyl]amino]cyclohexane-1-carboxylate
• CAS: 887245-70-7
• 化学式: C₂₉H₃₁N₃O₅
• 分子量: 501.582
• InChiKey: NOEAHRDXXZKNLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 4-oxo-1-({[3-({[(2,4,6-trimethylphenyl)amino]carbonyl}amino)-2-naphthalenyl]carbonyl}amino)cyclohexanecarboxylate 在 lithium hydroxide 、 水 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 4-Oxo-1-({[3-({[(2,4,6-trimethylphenyl)amino]carbonyl}amino)-2-naphthalenyl]carbonyl}amino)cyclohexanecarboxylic acid
  参考文献：
  名称：

  Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups

  摘要：

  Optimization of the amino acid residue within a series of anthranilimide-based glycogen phosphorylase inhibitors is described. These studies culminated in the identification of anthranilimides 16 and 22 which displayed potent in vitro inhibition of GPa in addition to reduced inhibition of CYP2C9 and excellent pharmacokinetic properties. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.085
• 作为产物：
  描述：

  Methyl 1-{[(3-amino-2-naphthalenyl)carbonyl]amino}-4-oxocyclohexanecarboxylate 、 2,4,6-三甲基苯基异氰酸酯 在 SiO2 、 methanol-dichloromethane 作用下， 以 吡啶 为溶剂， 反应 4.0h， 以Chromatography on SiO2 eluting with MeOH/CH2Cl2 afforded 0.84 g of product的产率得到Methyl 4-oxo-1-({[3-({[(2,4,6-trimethylphenyl)amino]carbonyl}amino)-2-naphthalenyl]carbonyl}amino)cyclohexanecarboxylate
  参考文献：
  名称：

  Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof

  摘要：

  本发明涉及糖原磷酸化酶抑制剂化合物、这些化合物的药物组合物、使用这些药物组合物治疗糖尿病、与糖尿病相关的疾病和/或组织缺血，包括心肌缺血的方法，以及制备这些化合物的过程。

  公开号：

  US20070249670A1

文献信息

• Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof
  申请人：Evans Karen

  公开号：US20070249670A1

  公开（公告）日：2007-10-25

  The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.

  本发明涉及糖原磷酸化酶抑制剂化合物、这些化合物的药物组合物、使用这些药物组合物治疗糖尿病、与糖尿病相关的疾病和/或组织缺血，包括心肌缺血的方法，以及制备这些化合物的过程。
• GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1812383A1

  公开（公告）日：2007-08-01
• [EN] GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] COMPOSES INHIBITEURS DE LA PHOSPHORYLASE DU GLYCOGENE ET COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2006052722A1

  公开（公告）日：2006-05-18

  [EN] The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.
  [FR] L'invention concerne des composés inhibiteurs de la phosphorylase de glycogène, des compositions pharmaceutiques contenant lesdits composés, des méthodes de traitement utilisées pour traiter le diabète, des états pathologiques associés au diabète et/ou à l'ischémie des tissus, notamment l'ischémie myocardique, et des procédés pour fabriquer les composés de l'invention.
• Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups
  作者：Steven M. Sparks、Pierette Banker、David M. Bickett、H. Luke Carter、Daphne C. Clancy、Scott H. Dickerson、Kate A. Dwornik、Dulce M. Garrido、Pamela L. Golden、Robert T. Nolte、Andrew J. Peat、Lauren R. Sheckler、Francis X. Tavares、Stephen A. Thomson、Liping Wang、James E. Weiel

  DOI：10.1016/j.bmcl.2008.11.085

  日期：2009.2

  Optimization of the amino acid residue within a series of anthranilimide-based glycogen phosphorylase inhibitors is described. These studies culminated in the identification of anthranilimides 16 and 22 which displayed potent in vitro inhibition of GPa in addition to reduced inhibition of CYP2C9 and excellent pharmacokinetic properties. (C) 2008 Elsevier Ltd. All rights reserved.