3-Methyl-1-(2-oxo-1,2-diphenyl-ethyl)-3H-imidazol-1-ium; chloride | 121704-70-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-Methyl-1-(2-oxo-1,2-diphenyl-ethyl)-3H-imidazol-1-ium; chloride
• 英文别名: 2-(3-Methylimidazol-3-ium-1-yl)-1,2-diphenylethanone;chloride
• CAS: 121704-70-9
• 化学式: C₁₈H₁₇N₂O*Cl
• 分子量: 312.799
• InChiKey: YBMPOFBWGRBXNN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.21
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  25.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基咪唑 、 2-氯-2-苯基苯乙酮 以 乙腈 为溶剂， 生成 3-Methyl-1-(2-oxo-1,2-diphenyl-ethyl)-3H-imidazol-1-ium; chloride
  参考文献：
  名称：

  Oral hypoglycemic agents. Discovery and structure-activity relationships of phenacylimidazolium halides

  摘要：

  Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides. Compounds 2 and 3 produced reductions of ca. 40% 2 h after doses of 100 mg/kg po. Since these mice do not respond to sulfonylureas, the glucose-lowering activity of phenacylimidazolium salts in this model suggests a mechanism other than that of stimulating insulin secretion. Only phenacylimidazolium halides with electron-donating groups were active; other azolium salts or variations in the phenacyl portion (alterations in the keto function; chain lengthening or extensive branching) produced inactive compounds.

  DOI：

  10.1021/jm00130a013

文献信息

• SPIKE SPECTRUM OUTPUT-TYPE PRESSURE SENSOR COMPRISING ELECTROLYTE, AND METHOD FOR MANUFACTURING SAME
  申请人：POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

  公开号：US20220136919A1

  公开（公告）日：2022-05-05

  Disclosed is a spike spectrum output-type pressure sensor including an electrolyte and a method of manufacturing the same. The pressure includes a first electrode, a pressure sensing unit positioned on the first electrode and including a pattern including an electrolyte, a spacer positioned on the first electrode and configured to partially or fully surround the pressure sensing unit, and a second electrode positioned on the spacer and on the pressure sensing unit and spaced apart from the pressure sensing unit. The pressure sensor of the present invention can provide reliable pressure sensing results even in an environment where noise may occur due to stable signal transmission of a spike spectrum, which is a kind of frequency-based signal.
• [EN] SPIKE HEAT OUTPUT-TYPE PRESSURE SENSOR COMPRISING ELECTROLYTE, AND METHOD FOR MANUFACTURING SAME<br/>[FR] CAPTEUR DE PRESSION DE TYPE À SORTIE DE CHALEUR DE POINTE COMPRENANT UN ÉLECTROLYTE ET SON PROCÉDÉ DE FABRICATION<br/>[KO] 전해질을 포함하는 스파이크열 출력형 압력센서 및 그의 제조방법
  申请人：POSTECH RES & BUSINESS DEV FOUND

  公开号：WO2020226288A1

  公开（公告）日：2020-11-12

  전해질을 포함하는 포함하는 스파이크열 출력형 압력센서 및 그의 제조방법이 개시된다. 상기 압력센서는 제1 전극; 상기 제1 전극 상에 위치하고, 전해질을 포함하는 패턴을 갖는 압력 감지부; 상기 제1 전극 상에 위치하고, 상기 압력 감지부의 일부 또는 전부를 둘러싸는 스페이서; 및 상기 스페이서와 상기 압력 감지부 상에 위치하고, 상기 압력 감지부와 이격하여 위치하는 제2 전극; 을 포함한다. 본 발명의 압력센서는 주파수 기반 신호의 일종인 스파이크열의 안정적 신호 전달로 노이즈가 발생할 수 있는 환경에서도 신뢰성 있는 압력 센싱 결과를 제시할 수 있다.
• Oral hypoglycemic agents. Discovery and structure-activity relationships of phenacylimidazolium halides
  作者：Samuel J. Dominianni、Terence T. Yen

  DOI：10.1021/jm00130a013

  日期：1989.10

  Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides. Compounds 2 and 3 produced reductions of ca. 40% 2 h after doses of 100 mg/kg po. Since these mice do not respond to sulfonylureas, the glucose-lowering activity of phenacylimidazolium salts in this model suggests a mechanism other than that of stimulating insulin secretion. Only phenacylimidazolium halides with electron-donating groups were active; other azolium salts or variations in the phenacyl portion (alterations in the keto function; chain lengthening or extensive branching) produced inactive compounds.