3-(2-Hydroxy-4,6-dimethyl-phenyl)-3-methyl-butyric acid | 40662-08-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(2-Hydroxy-4,6-dimethyl-phenyl)-3-methyl-butyric acid
• 英文别名: 3-(2'-Hydroxy-4',6'-dimethylphenyl)-3,3-dimethyl propionic acid；3-(2-hydroxy-4,6-dimethylphenyl)-3-methylbutanoic acid
• CAS: 40662-08-6
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: UVQGLJHJZLVTQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-Hydroxy-4,6-dimethyl-phenyl)-3-methyl-butyric acid 生成 4,4,5,7-tetramethyl-3,4-dihydrocoumarin
  参考文献：
  名称：

  Tetrahedral intermediate in acyl transfer reactions. A revaluation of the significance of rate data used in deriving fundamental linear free energy relationships

  摘要：

  DOI：

  10.1021/ja00389a051
• 作为产物：
  描述：

  4,4,5,7-tetramethyl-3,4-dihydrocoumarin 在 水 作用下， 以 乙二醇二甲醚 为溶剂， 生成 3-(2-Hydroxy-4,6-dimethyl-phenyl)-3-methyl-butyric acid
  参考文献：
  名称：

  Formation and hydrolysis of lactones of phenolic acids

  摘要：

  DOI：

  10.1021/ja00534a041

文献信息

• [EN] HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF<br/>[FR] PRÉCURSEURS DE SULFURE D'HYDROGÈNE ET CONJUGUÉS DE CES DERNIERS
  申请人：GEORGIA STATE UNIV RES FOUND

  公开号：WO2016161445A1

  公开（公告）日：2016-10-06

  The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula (I) are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.

  本发明提供了形成硫化氢的方法。该方法包括将前体化合物与解掩蔽剂接触；其中前体化合物包括释放硫化氢的基团和掩蔽的亲核试剂；并且在足以使前体化合物通过内酯或内酰胺形成环化的条件下进行接触；从而从前体化合物释放硫化氢。还描述了符合式(I)的硫化氢前体化合物，以及使用硫化氢前体化合物治疗疾病和病况的方法。
• [EN] COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY<br/>[FR] COMPOSITIONS ET MÉTHODES D'ADMINISTRATION CIBLÉE D'ARN
  申请人：VERVE THERAPEUTICS INC

  公开号：WO2021178725A1

  公开（公告）日：2021-09-10

  Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.

  本文提供了组合物、制备方法以及用于靶向传递治疗剂以修改靶基因表达和功能的方法，例如涉及脂质和胆固醇代谢的蛋白质，如PCSK9。此外，还提供了与冠心病相关疾病的治疗组合物和方法。
• Autophagy-inducing peptide analogs
  申请人：Board of Regents, The University of Texas System

  公开号：US10300106B2

  公开（公告）日：2019-05-28

  An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties R1 and R2, respectively, wherein up to six of said peptide residues may be substituted, R1 and R2 do not naturally flank the Beclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.

  自噬诱导化合物包括自噬诱导肽，该肽包含紧靠N端和C端分别由分子R1和R2侧翼的Beclin 1肽，其中所述肽残基中最多可有6个残基被取代，R1和R2不是天然侧翼的Beclin 1残基，F270和F274被任选取代和任选连接。这些化合物可用于诱导自噬。
• Hydrogen sulfide precursors and conjugates thereof
  申请人：Georgia State University Research Foundation, Inc.

  公开号：US10689335B2

  公开（公告）日：2020-06-23

  The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.

  本发明提供了形成硫化氢的方法。这些方法包括将前体化合物与解蔽剂接触；其中，前体化合物包括硫化氢释放分子和被掩蔽的亲核体；接触在足以使前体化合物通过内酯或内酰胺形成环化的条件下进行；从而从前体化合物中释放硫化氢。还描述了根据式 I 的硫化氢前体化合物，以及使用硫化氢前体治疗疾病和病症的方法。
• Compositions and methods for targeted RNA delivery
  申请人：Verve Therapeutics, Inc.

  公开号：US11207416B2

  公开（公告）日：2021-12-28

  Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.

  本发明提供了组合物、制备该组合物的方法、以及用于靶向递送治疗剂以修改靶基因表达和功能的组合物和方法，例如涉及脂质和胆固醇代谢的蛋白质，如PCSK9。此外，还提供了治疗与冠状动脉疾病相关状况的组合物和方法。