Ethyl 3-(1-piperazinyl)-3-oxopropionate | 224309-82-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Ethyl 3-(1-piperazinyl)-3-oxopropionate
• 英文别名: Ethyl I(2)-oxo-1-piperazinepropanoate；ethyl 3-oxo-3-piperazin-1-ylpropanoate
• CAS: 224309-82-4
• 化学式: C₉H₁₆N₂O₃
• 分子量: 200.238
• InChiKey: LNLDSHMSSHBVAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 3-(1-piperazinyl)-3-oxopropionate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-Oxo-3-[4-(2-pyridin-4-yl-2,8-diaza-spiro[4.5]decane-8-carbonyl)-piperazin-1-yl]-propionic acid ethyl ester
  参考文献：
  名称：

  Spirocyclic nonpeptide glycoprotein IIb–IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes

  摘要：

  The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro structures as central template for nonpeptide RGD mimics. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00095-1
• 作为产物：
  描述：

  4-(2-Ethoxycarbonyl-acetyl)-piperazine-1-carboxylic acid benzyl ester 在 palladium dihydroxide 氢气 作用下， 以 乙醇 为溶剂， 生成 Ethyl 3-(1-piperazinyl)-3-oxopropionate
  参考文献：
  名称：

  Spirocyclic nonpeptide glycoprotein IIb–IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes

  摘要：

  The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro structures as central template for nonpeptide RGD mimics. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00095-1

文献信息

• NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
  申请人：Sundaresan Kumar

  公开号：US20090239848A1

  公开（公告）日：2009-09-24

  The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

  本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。该发明还涉及制备这些化合物的方法、含有这些化合物的组合物，以及使用这些化合物进行治疗的方法。
• Optical active 1,4-dihydropyridine compounds as bradykinin antagonists
  申请人：PFIZER INC.

  公开号：EP0899261A1

  公开（公告）日：1999-03-03

  This invention provides a compound of the formula (I): and its pharmaceutically acceptable salts, wherein A1 and A2 are each halo; R1 and R2 are independently C1-4 alkyl; R3 is substituted or unsubstituted, phenyl or naphthyl; Y is heterocyclic group selected from C5-10 azacycloalkyl, C6-10 diazacycloalkyl, C7-10 azabicycloalkyl and the like; and R4 is selected from (a) substituted or unsubstituted C1-8 alkyll; (b) substituted or unsubstituted amino; (c) substituted or unsubstituted C2-6 alkanoyl; (d) substituted or unsubstituted C3-8 cycloalkyl or C7-14 bicycloalkyl; (e) substituted or unsubstituted C5-10 azacycloalkyl or C6-10 diazacycloalkyl, and (f) substituted or unsubstituted C7-14 mono- or di-azabicycloalkyl. These compounds are useful for the treatment of medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound, and intermediates of the above compounds.

  本发明提供了一种式（I）化合物： 及其药学上可接受的盐类，其中 A1 和 A2 各为卤代；R1 和 R2 独立地为 C1-4 烷基；R3 为取代或未取代的苯基或萘基；Y 为杂环基团，选自 C5-10 氮杂环烷基、C6-10 二氮杂环烷基、C7-10 氮杂双环烷基等；R4 选自 (a) 取代或未取代的 C1-8 烷基；(b) 取代或未取代的氨基； (c) 取代或未取代的 C2-6 烷酰基； (d) 取代或未取代的 C3-8 环烷基或 C7-14 双环烷基； (e) 取代或未取代的 C5-10 氮杂环烷基或 C6-10 二氮杂环烷基，以及 (f) 取代或未取代的 C7-14 单氮杂双环烷基或双氮杂双环烷基。这些化合物可用于治疗由缓激肽引起的病症，如炎症、心血管疾病、疼痛等。本发明还提供了一种药物组合物，其中包含上述化合物以及上述化合物的中间体。
• NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE
  申请人：Forest Laboratories Holdings Limited

  公开号：EP2307023A1

  公开（公告）日：2011-04-13
• US6156752A
  申请人：——

  公开号：US6156752A

  公开（公告）日：2000-12-05
• US8039463B2
  申请人：——

  公开号：US8039463B2

  公开（公告）日：2011-10-18