ethyl 2-carbethoxy-3-cyano-3-(2-naphthyl)propionate | 1217022-76-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ethyl 2-carbethoxy-3-cyano-3-(2-naphthyl)propionate
• 英文别名: Diethyl 2-[cyano(naphthalen-2-yl)methyl]propanedioate；diethyl 2-[cyano(naphthalen-2-yl)methyl]propanedioate
• CAS: 1217022-76-8
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.364
• InChiKey: CMHTVLUDXHTJES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  76.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  diethyl 2-(naphthalen-2-ylmethylene)malonate 、 三甲基氰硅烷 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 ethyl 2-carbethoxy-3-cyano-3-(2-naphthyl)propionate
  参考文献：
  名称：

  Asymmetric Cyanation of Activated Olefins with Ethyl Cyanoformate Catalyzed by a Modular Titanium Catalyst

  摘要：

  Asymmetric cyanation of a class of easily available olefins with a favorable cyanide source ethyl cyanoformate (CNCOOEt) was realized by an interesting modular catalyst. High yields and ee values were obtained for a range of substrates under solvent-free and mild reaction conditions. The products obtained could be easily transformed to the enantioenriched useful intermediates 5, 6, and pharmaceutically important gamma-aminobutyric acid 7.

  DOI：

  10.1021/ol100169r

文献信息

• Asymmetric Cyanation of Activated Olefins with Ethyl Cyanoformate Catalyzed by a Modular Titanium Catalyst
  作者：Jun Wang、Wei Li、Yanling Liu、Yangyang Chu、Lili Lin、Xiaohua Liu、Xiaoming Feng

  DOI：10.1021/ol100169r

  日期：2010.3.19

  Asymmetric cyanation of a class of easily available olefins with a favorable cyanide source ethyl cyanoformate (CNCOOEt) was realized by an interesting modular catalyst. High yields and ee values were obtained for a range of substrates under solvent-free and mild reaction conditions. The products obtained could be easily transformed to the enantioenriched useful intermediates 5, 6, and pharmaceutically important gamma-aminobutyric acid 7.