2-propyl-dibenzofuran | 92548-73-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-propyl-dibenzofuran
• 英文别名: 2-Propyldibenzofuran
• CAS: 92548-73-7
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: GRHZPFRMDUAUMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-propyl-dibenzofuran 、 乙酰氯 在 二硫化碳 、 三氯化铝 作用下， 生成 2-Acetyl-7-propyl-dibenzofuran
  参考文献：
  名称：

  Buu-Hoi; Royer, Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 861,867

  摘要：

  DOI：
• 作为产物：
  描述：

  2-propionyldibenzofuran 在 盐酸 、 amalgamated zinc 、 甲苯 作用下， 生成 2-propyl-dibenzofuran
  参考文献：
  名称：

  Buu-Hoi; Royer, Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 861,867

  摘要：

  DOI：

文献信息

• INHIBITORS OF PROTEIN KINASES
  申请人：PORTOLA PHARMACEUTICALS, INC.

  公开号：US20180186783A1

  公开（公告）日：2018-07-05

  The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
• [EN] ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME<br/>[FR] COMPOSÉ ORGANIQUE ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE LE COMPRENANT<br/>[KO] 유기 화합물 및 이를 포함하는 유기 전계 발광 소자
  申请人：SOLUS ADVANCED MAT CO LTD

  公开号：WO2021034081A1

  公开（公告）日：2021-02-25

  본 발명은 전자 수송능, 발광능 및 열적 안정성이 우수한 신규 화합물 및 이를 하나 이상의 유기물층에 포함함으로써 발광효율, 구동 전압, 수명 등의 특성이 향상된 유기 전계 발광 소자에 관한 것이다.
• [EN] 5-AMINO-2-PIPERIDINON-3-YL-1-OXOISOINDOLINE DERIVATIVES FOR DEGRADATION OF IKZF2 DEGRADERS<br/>[FR] DÉRIVÉS DE 5-AMINO-2-PIPÉRIDINON-3-YL-1-OXOISOINDOLINE POUR LA DÉGRADATION DES AGENTS DE DÉGRADATION IKZF2
  申请人：HARVARD COLLEGE

  公开号：WO2021222542A1

  公开（公告）日：2021-11-04

  Provided herein are compounds that promote targeted degradation of IKZF2, a protein whose activity is implicated in the pathology of certain cancers (e.g., acute myeloid leukemia). Also provided are pharmaceutical compositions comprising the compounds. Also provided are methods of treating cancer, and methods of promoting the degradation of IKZF2 in a subject or biological sample by administering a compound or composition described herein.