N,N'-Dipentyl-ethylendiamin | 88619-07-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-Dipentyl-ethylendiamin
• 英文别名: N,N'-dipentyl-ethylenediamine；N,N'-Dipentyl-aethylendiamin；N,N'-dipentylethane-1,2-diamine
• CAS: 88619-07-2
• 化学式: C₁₂H₂₈N₂
• 分子量: 200.368
• InChiKey: PHKIRJNNBPMGKY-UHFFFAOYSA-N

物化性质

• 沸点：
  149 °C(Press: 26 Torr)
• 密度：
  0.8302 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N'-dipentyl-N,N'-ethanediyl-bis-toluene-4-sulfonamide 在 硫酸 作用下， 生成 N,N'-Dipentyl-ethylendiamin
  参考文献：
  名称：

  Vyas; Dhopate, Journal Of Scientific and Industrial Research, 1959, vol. 18 C, p. 6,9

  摘要：

  DOI：

文献信息

• DIACYLETHYLENEDIAMINE COMPOUND
  申请人：Kawano Tomoaki

  公开号：US20120046292A1

  公开（公告）日：2012-02-23

  [Problem] A compound which is useful as an anti-obesity agent is provided. [Means for Solution] The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases, and as a result, they have found that the diacylethylenediamine compound of the present invention has an excellent DGAT1 inhibitory action, thereby completing the present invention. That is, the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.

  提供一种作为抗肥胖剂的化合物。现发明人调查了一种具有DGAT1抑制作用的化合物，该化合物有望成为治疗肥胖、2型糖尿病、脂肪肝以及与这些疾病相关的疾病的药物组合物的有效成分，并且他们发现了本发明的二酰乙二胺化合物具有出色的DGAT1抑制作用，从而完成了本发明。也就是说，本发明的二酰乙二胺化合物具有DGAT1抑制作用，因此可用作预防和/或治疗肥胖、2型糖尿病、脂肪肝以及与这些疾病相关的药物。
• Process for preparation of pentostatin (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz[4,5-d][1,3] diazepin-8-ol
  申请人：Zhang Hai-Ren

  公开号：US20090012288A1

  公开（公告）日：2009-01-08

  In a process for preparing pentostatin, the improvement wherein reduction is performed on ketone prior to deprotection, comprising: a) reacting 3-(2-deoxy-3,5-di-O-p-toluoyl-b-D-erythro-pentofuranosyl)-6,7-dihydroimidazol [4,5-d][1,3] diazepin-8 (3H)-one with a ruthenium catalyst formed by the reaction of di-μ-chlorobis[(p-cymene) chlororuthenium (II) and N-(arylsulfonyl)-1,2-diarylethylene diamine in a solvent; b) stopping the reaction in step a) by making the reaction medium alkaline; c) separating the mixture from step b) into combined organic layers and washing the reaction product from the combined organic layers with water, filtering, and evaporating solvent to provide a crude product, wherein the ratio of 8R vs 8S isomeric alcohol >100; d) purifying said crude product by chromatography; e) deprotecting the keto nucleoside in the crude product in methanol/sodium methoxide to obtain pentostatin; and f) purifying by recrystallizing pentostatin from methanol to remove inorganic and isomeric impurities.

  一种制备戊糖霉素的方法，改进在去保护前对酮进行还原，包括： a) 在溶剂中用二-μ-氯化双[(对二甲苯)氯合铑(II)]和N-(芳基磺酰基)-1,2-二芳基乙二胺反应形成的钌催化剂与3-(2-脱氧-3,5-二-O-p-甲苯基-β-D-erythro-戊呋糖基)-6,7-二氢咪唑[4,5-d][1,3]二氮杂环己烷-8(3H)-酮反应； b) 通过使反应介质碱性停止步骤a)中的反应； c) 将步骤b)中的混合物分离成组合的有机层，并用水洗涤组合的有机层中的反应产物，过滤并蒸发溶剂以提供粗品，其中8R与8S异构醇的比值>100； d) 通过色谱法纯化所述粗品； e) 在甲醇/甲氧基钠中去保护粗品中的酮核苷，以获得戊糖霉素； f) 通过在甲醇中重结晶戊糖霉素以去除无机和异构杂质。
• N,N'diacyl-ethane-1,2 diamines, their preparation and their pesticidal formulations
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0019294A1

  公开（公告）日：1980-11-26

  Compounds of formula (I) are pesticides active against arthropods. wherein R1, R2, and R3 are H, alkyl, alkoxy, halo, CN or CF3 or two are linked to form a 3 or 4 carbon atom group; X is 0 or NA where A is H or alkyl; R is H or alkyl; R4 is H or optionally substituted alkyl, aryl, aralkyl, alkenyl or alkynyl; and R5 is -CB. R5 where B is O, S or NR7 where R7 is H, alkyl. alkoxy, or optionally substituted aryl or aralkyl; R6 is H, R8, OR6, SR8 or NR9 R10 where R4 is alkyl, alkenyl or optionally substituted aralkyl or aryloxyalkyl; and R9 and R10 are H, alkyl or optionally substituted aryl or aralkyl; The invention also comprises processes for the preparation of compounds (1), formulations containing them, and their use as pesticides.

  式(I)化合物是对节肢动物具有活性的杀虫剂。 其中 R1、R2 和 R3 为 H、烷基、烷氧基、卤代、CN 或 CF3，或两个相连形成 3 或 4 个碳原子基团； X 是 0 或 NA，其中 A 是 H 或烷基； R 是 H 或烷基； R4 是 H 或任选取代的烷基、芳基、芳烷基、烯基或炔基； R5 是-CB。R5 其中 B 是 O、S 或 NR7，其中 R7 是 H、烷基、烷氧基或任选取代的芳基或芳烷基； R6 是 H、R8、OR6、SR8 或 NR9 R10，其中 R4 是烷基、烯基或任选取代的芳基或芳氧基烷基； R9 和 R10 是 H、烷基或任选取代的芳基或芳烷基； 本发明还包括化合物（1）的制备工艺、含有化合物（1）的制剂及其农药用途。
• Shepherd,R.G.; Wilkinson,R.G., Journal of medicinal and pharmaceutical chemistry, 1962, vol. 5, p. 823 - 835
  作者：Shepherd,R.G.、Wilkinson,R.G.

  DOI：——

  日期：——
• King; McMillan, Journal of the American Chemical Society, 1946, vol. 68, p. 1776
  作者：King、McMillan

  DOI：——

  日期：——