5-methanesulfonyl-1-oxiranylmethyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 、
6-Chloro-4-piperidin-4-yl-4H-benzo[1,4]oxazin-3-one 在
三乙胺 作用下,
以
乙醇 、
乙酸乙酯 为溶剂,
以191 mg (55%)的产率得到6-Chloro-4-(1-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperidin-4-yl)-4H-benzo[1,4]oxazin-3-one