tert-butyl-[[(3S,5S,8S,9S,10S,13S,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-diphenylsilane | 1245773-27-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: tert-butyl-[[(3S,5S,8S,9S,10S,13S,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-diphenylsilane
• CAS: 1245773-27-6
• 化学式: C₃₅H₅₀OSi
• 分子量: 514.867
• InChiKey: JSWAQIOYFHRMGX-VZWUGWNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.36
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-(t-butyl)diphenylsiloxy-androstan-17-one 在 三甲基氯硅烷 、 锌 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 以90%的产率得到tert-butyl-[[(3S,5S,8S,9S,10S,13S,14S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-diphenylsilane
  参考文献：
  名称：

  One-pot reductive cleavage of exo-olefin to methylene with a mild ozonolysis-Clemmensen reduction sequence

  摘要：

  A one-pot exo-olefin reductive cleavage was for the first time developed. The reaction could proceed under a mild condition avoiding the use of hazardous and expensive reagents. Meanwhile, a TMSCl-mediated Clemmensen reduction in alcoholic solvent was also examined. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.102

文献信息

• One-pot reductive cleavage of exo-olefin to methylene with a mild ozonolysis-Clemmensen reduction sequence
  作者：Shu Xu、Takayuki Toyama、Jun Nakamura、Hirokazu Arimoto

  DOI：10.1016/j.tetlet.2010.06.102

  日期：2010.8

  A one-pot exo-olefin reductive cleavage was for the first time developed. The reaction could proceed under a mild condition avoiding the use of hazardous and expensive reagents. Meanwhile, a TMSCl-mediated Clemmensen reduction in alcoholic solvent was also examined. (C) 2010 Elsevier Ltd. All rights reserved.