N-isobutyldodecan-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-isobutyldodecan-1-amine
• 英文别名: N-n-dodecyl-isobutylamine；N-(2-methylpropyl)dodecan-1-amine
• 化学式: C₁₆H₃₅N
• mdl: MFCD18918449
• 分子量: 241.461
• InChiKey: LNIJOCDFSOYTOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(2-methylpropyl)dodecanamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以67%的产率得到N-isobutyldodecan-1-amine
  参考文献：
  名称：

  Synthesis and biological evaluation of a series of fatty acid amides from Echinacea

  摘要：

  Alkylamides are lipophilic constituents of Echinacea and possess numerous biological activities. Although significant effort has been focused on the study of crude Echinacea extracts, very little is known regarding the activities of the individual constituents that make up these herbal treatments. Herein we explore the SAR of simple alkylamides found in Echinacea extracts with respect to their ability to decrease the production of the pro-inflammatory mediator TNF-alpha. Our results have revealed the key structural requirements for activity and provide lead compounds for further investigation of these poorly understood molecules. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.06.024

文献信息

• A method for improving cold flow of hydrocarbon fuel oils
  申请人：NIPPON OIL AND FATS COMPANY, LIMITED

  公开号：EP0326356A1

  公开（公告）日：1989-08-02

  A method is disclosed for improving low temperature cold flow of fuel oils by using a cross-­linked ester compound consisting essentially of a nitrogen-containing compound having hydroxyl group, a straight chain fatty acid, and a cross-linking agent.

  本发明公开了一种使用交联酯化合物改善燃料油低温冷流动性的方法，交联酯化合物主要由具有羟基的含氮化合物、直链脂肪酸和交联剂组成。
• DIALKYLAMINOALKANOL FRICTION MODIFIERS FOR FUELS AND LUBRICANTS
  申请人：Afton Chemical Corporation

  公开号：EP3178909A1

  公开（公告）日：2017-06-14

  A fuel composition, a lubricant composition, and methods for reducing friction or wear of moving parts. The fuel composition includes gasoline and from about 10 to about 500 ppm by weight of a dialkylaminoalkanol of the formula R1(R2)NCH2CH(R3)R4. The lubricant composition includes base oil of lubricating viscosity and from about 0.05 to about 5.0 weight percent of a dialkylaminoalkanol of the formula R1(R2)NCH2CH(R3)R4. In the above formulas wherein R1 is an alkyl group or a hydroxyalkyl group containing from 8 to 50 carbon atoms; R2 is an alkyl group containing from 1 to 4 carbon atoms; R3 is selected from H and OH; and R4 is selected from H, an alkyl group containing from 1 to 4 carbon atoms, and CH2OH and wherein at least one of R3 and R4 contains a hydroxyl group and provided that when R1 is a hydroxyalkyl group, R3 is OH and R4 is CH2OH.

  一种燃料组合物、一种润滑剂组合物和减少运动部件摩擦或磨损的方法。燃料组合物包括汽油和按重量计约 10 至约 500ppm 的式 R1(R2)NCH2CH(R3)R4 的二烷基氨基烷醇。润滑剂组合物包括具有润滑粘度的基础油和约 0.05 至约 5.0 重量百分比的式 R1(R2)NCH2CH(R3)R4 的二烷基氨基烷醇。在上述配方中，其中 R1 是含有 8 至 50 个碳原子的烷基或羟烷基；R2 是含有 1 至 4 个碳原子的烷基；R3 选自 H 和 OH；R4 选自 H、含有 1 至 4 个碳原子的烷基和 CH2OH，且 R3 和 R4 中至少有一个含有羟基，条件是当 R1 是羟烷基时，R3 是 OH，R4 是 CH2OH。
• Dialkylaminoalkanol friction modifiers for fuels and lubricants
  申请人：Afton Chemical Corporation

  公开号：US10407636B2

  公开（公告）日：2019-09-10

  A fuel composition, a lubricant composition, and methods for reducing friction or wear of moving parts. The fuel composition includes gasoline and from about 10 to about 500 ppm by weight of a dialkylaminoalkanol of the formula R1(R2)NCH2CH(R3)R4. The lubricant composition includes base oil of lubricating viscosity and from about 0.05 to about 5.0 weight percent of a dialkylaminoalkanol of the formula R1(R2)NCH2CH(R3)R4. In the above formulas wherein R1 is an alkyl group or a hydroxy alkyl group containing from 8 to 50 carbon atoms; R2 is an alkyl group containing from 1 to 4 carbon atoms; R3 is selected from H and OH; and R4 is selected from H, an alkyl group containing from 1 to 4 carbon atoms, and CH2OH and wherein at least one of R3 and R4 contains a hydroxyl group and provided that when R1 is a hydroxyalkyl group, R3 is OH and R4 is CH2OH.

  一种燃料组合物、一种润滑剂组合物和减少运动部件摩擦或磨损的方法。燃料组合物包括汽油和按重量计约 10 至约 500ppm 的式 R1(R2)NCH2CH(R3)R4 的二烷基氨基烷醇。润滑剂组合物包括具有润滑粘度的基础油和约 0.05 至约 5.0 重量百分比的式 R1(R2)NCH2CH(R3)R4 的二烷基氨基烷醇。在上述公式中，其中 R1 是含有 8 至 50 个碳原子的烷基或羟基烷基；R2 是含有 1 至 4 个碳原子的烷基；R3 选自 H 和 OH；R4 选自 H、含有 1 至 4 个碳原子的烷基和 CH2OH，且 R3 和 R4 中至少有一个含有羟基，条件是当 R1 是羟基烷基时，R3 是 OH，R4 是 CH2OH。
• Dialkyaminoalkanol Friction Modifiers For Fuels And Lubricants
  申请人：Afton Chemical Corporation

  公开号：US20170166826A1

  公开（公告）日：2017-06-15

  A fuel composition, a lubricant composition, and methods for reducing friction or wear of moving parts. The fuel composition includes gasoline and from about 10 to about 500 ppm by weight of a dialkylaminoalkanol of the formula R 1 (R 2 )NCH 2 CH(R 3 )R 4 . The lubricant composition includes base oil of lubricating viscosity and from about 0.05 to about 5.0 weight percent of a dialkylaminoalkanol of the formula R 1 (R 2 )NCH 2 CH(R 3 )R 4 . In the above formulas wherein R 1 is an alkyl group or a hydroxyalkyl group containing from 8 to 50 carbon atoms; R 2 is an alkyl group containing from 1 to 4 carbon atoms; R 3 is selected from H and OH; and R 4 is selected from H, an alkyl group containing from 1 to 4 carbon atoms, and CH 2 OH and wherein at least one of R 3 and R 4 contains a hydroxyl group and provided that when R 1 is a hydroxyalkyl group, R 3 is OH and R 4 is CH 2 OH.
• MERTK DEGRADERS AND USES THEREOF
  申请人：Kymera Therapeutics, Inc.

  公开号：US20220356185A1

  公开（公告）日：2022-11-10

  The present invention provides compounds, compositions thereof, and methods of using the same.