hexahydro-2,6-methano-1H-pyrrolizin-8-one | 70075-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯里西啶类
• 英文名称: hexahydro-2,6-methano-1H-pyrrolizin-8-one
• 英文别名: 3-Azatricyclo[3.3.1.03,7]nonan-9-one
• CAS: 70075-72-8
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: WOQGEAGUFDIOAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  hexahydro-2,6-methano-1H-pyrrolizin-8-one 在 吡啶 、 2-甲基-2-丁醇 、 sodium 作用下， 以 乙醇 为溶剂， 生成 (2R,6S,7as,8r)-hexahydro-1H-2,6-methanopyrrolizin-8-amine
  参考文献：
  名称：

  Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamides

  摘要：

  A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4 agonist in the series, with an EC50 of 217 nM. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00408-3

文献信息

• [EN] MUSCARINIC AGONISTS AND ANTAGONISTS<br/>[FR] AGONISTES ET ANTAGONISTES MUSCARINIQUES
  申请人：UCB SA

  公开号：WO2000011001A1

  公开（公告）日：2000-03-02

  The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.

  本发明提供了一种新型化合物及其药物组合物，可用于治疗疼痛。本发明的化合物是氮杂莫来达烷，氮杂诺来达烷和氮杂同构莫来达烷。
• Muscarinic agonists and antagonists
  申请人：——

  公开号：US20020045617A1

  公开（公告）日：2002-04-18

  The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.

  本发明提供了可用于治疗疼痛的新型化合物及其药物组合物。本发明的化合物是氮杂金刚烷、氮杂金刚烷和氮杂高金刚烷。
• Effect of Remote Substitution on Face Selection in Addition Reactions of Nor- and Homoadamantan-9-ones and of Several Analogues
  作者：Mira Kaselj、Elena M. Gonikberg、William J. le Noble

  DOI：10.1021/jo9718197

  日期：1998.5.1

  The effects of 3-halo substitution on face selection in borohydride reductions of both nor-and homoadamantan-9-ones l-X and 3-X. respectively, have been compared with those of 5-halo substitution in the parent 5-haloadamantan-2-ones 2-X, The differences between the product ratios in these three compounds are small, but the selectivity of 2-X is somewhat larger than that of either of the homologues. This is also true of the corresponding aza-and diazaadamantanones, and of an electrophilic addition. It is concluded that the approach angle of the reagent is not a sensitive variable in addition reactions of cyclohexanone and its derivatives, and that well-aligned antiperiplanar bonds are preferred to achieve maximal remote substituent induced selectivities.
• MUSCARINIC AGONISTS AND ANTAGONISTS
  申请人：UCB, S.A.

  公开号：EP1112272A1

  公开（公告）日：2001-07-04
• US5530018A
  申请人：——

  公开号：US5530018A

  公开（公告）日：1996-06-25