5-diethylamino-2-aminohexane | 255717-96-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-diethylamino-2-aminohexane
• 英文别名: N⁵,N⁵-diethyl-1-methyl-pentanediyldiamine；N⁵,N⁵-Diaethyl-1-methyl-pentandiyldiamin；1-N,1-N-diethylhexane-1,5-diamine
• CAS: 255717-96-5
• 化学式: C₁₀H₂₄N₂
• 分子量: 172.314
• InChiKey: CXFWUXVSDOBHSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-diethylamino-2-aminohexane 、 6,9-二氯-2-甲氧基吖啶 在 苯酚 作用下， 反应 2.0h， 生成 N⁵,N⁵-diethyl-N¹-(6-chloro-2-methoxy-acridin-9-yl)-1-methyl-pentanediyldiamine
  参考文献：
  名称：

  Inhibition of Trypanosoma cruzi Trypanothione Reductase by Acridines:  Kinetic Studies and Structure−Activity Relationships

  摘要：

  Series of 9-amino and 9-thioacridines have been synthesized and studied as inhibitors of trypanothione reductase (TR) from Trypanosoma cruzi, the causative agent; of Chagas' disease. The compounds are structural analogues of the acridine drug mepacrine (quinacrine), which is a competitive inhibitor of the parasite enzyme, but not of human glutathione reductase, the closest related host enzyme. The 9-aminoacridines yielded apparent K-i values for competitive inhibition between 5 and 43 mu M. The most effective inhibitors were those with the methoxy and chlorine substituents of mepacrine and NH2 or NHCH(CH3)(CH2)(4)N(Et)(2) at C9. Detailed kinetic analyses revealed that in the case of 9-aminoacridines more than one inhibitor molecule can bind to the enzyme. In contrast, the 9-thioacridine derivatives inhibit TR with mixed-type kinetics. The kinetic data are discussed in light of the three-dimensional structure of the TR-mepacrine complex. The conclusion that structurally very similar acridine compounds can give rise to completely different inhibition patterns renders modelling studies and quantitative structure-activity relationships difficult.

  DOI：

  10.1021/jm990386s
• 作为产物：
  描述：

  6-diethylamino-hexan-2-one oxime 在 sodium 、 正丁醇 作用下， 生成 5-diethylamino-2-aminohexane
  参考文献：
  名称：

  1-二乙基氨基-5-氨基己烷的合成。

  摘要：

  DOI：

  10.1021/ja01211a052

文献信息

• 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
  申请人：Luk Kin-Chun

  公开号：US20050256154A1

  公开（公告）日：2005-11-17

  Disclosed are novel 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides, and their pharmaceutically acceptable salts and esters, that are selective inhibitors of KDR and/or FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular solid cancerous tumors of the breast, colon, lung and prostate. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer using these compounds.

  本文披露了一种新颖的4-氨基噻吩[3,2-c]吡啶-7-羧酸酰胺，以及它们的药用盐和酯，这些化合物是KDR和/或FGFR激酶的选择性抑制剂。这些化合物及其药用盐是抗增殖剂，可用于治疗或控制实体肿瘤，特别是乳腺、结肠、肺和前列腺的实体癌性肿瘤。还披露了含有这些化合物的药物组合物和使用这些化合物治疗癌症的方法。
• NOVEL 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID AMIDES
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1917015A1

  公开（公告）日：2008-05-07
• US4054553A
  申请人：——

  公开号：US4054553A

  公开（公告）日：1977-10-18
• US4098846A
  申请人：——

  公开号：US4098846A

  公开（公告）日：1978-07-04
• [EN] NOVEL 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID AMIDES<br/>[FR] NOUVEAUX AMIDES DE L'ACIDE 4-AMINO-THIÉNO[3,2-C]PYRIDINE-7-CARBOXYLIQUE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2007019884A1

  公开（公告）日：2007-02-22

  [EN] The present invention relates to novel 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides of formula (I), and their pharmaceutically acceptable salts and esters which compounds of formula (I) are selective inhibitors of KDR and/or FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular solid tumors of the breast, colon, lung and prostate. Also disclosed are pharmaceutical compositions or medicaments containing these compounds, processes for making them and methods of treating cancer using these compounds.
  [FR] La présente invention concerne de nouveaux amides de l'acide 4-amino-thiéno[3,2-c]pyridine-7-carboxylique répondant à la formule I, et leurs sels et esters pharmaceutiquement acceptables, lesquels composés répondant à la formule I étant des inhibiteurs sélectifs de KDR et/ou FGFR kinases. Ces composés et leurs sels pharmaceutiquement acceptables sont des agents anti-prolifératifs utiles dans le traitement ou la lutte contre des tumeurs solides, en particulier les tumeurs solides du sein, du colon, du poumon et de la prostate. En outre, la présente invention concerne des compositions pharmaceutiques ou des médicaments contenant ces composés, leurs procédés de fabrication et des procédés de traitement du cancer utilisant ces composés.