(R)-N,N-bis(2-diphenylphosphinoethyl)-1-phenyl-ethylamine | 81510-19-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-N,N-bis(2-diphenylphosphinoethyl)-1-phenyl-ethylamine
• 英文别名: (R)-(+)-N,N-Bis(2-diphenylphosphinoethyl)-1-phenylethylamine；(1R)-N,N-bis(2-diphenylphosphanylethyl)-1-phenylethanamine
• CAS: 81510-19-2
• 化学式: C₃₆H₃₇NP₂
• 分子量: 545.644
• InChiKey: ZVNAHLJBPYKGBV-WJOKGBTCSA-N

物化性质

• 熔点：
  63-65 °C
• 沸点：
  632.8±45.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  bis(benzonitrile)dichloroplatinum(II) 、 (R)-N,N-bis(2-diphenylphosphinoethyl)-1-phenyl-ethylamine 以 苯 为溶剂， 以85%的产率得到cis-[PtCl2((R)-N,N-bis(2-diphenylphosphinoethyl)-1-phenyl-ethylamine)]
  参考文献：
  名称：

  Platinum complexes of (R)-N,N-bis(2-(diphenylphosphino)ethyl)-1-phenyl-ethylamine: their synthesis and characterisation

  摘要：

  Both neutral and ionic platinum complexes of (R)-N,N-bis-(2-diphenylpho sphinoethyl)-1-phenyl-ethylamine (PNP) were synthesised. In the reaction of PtCl2(PhCN)(2) and PNP cis-PtCl2(eta (2)-P,P-PNP) (1) was formed coordinating PNP as a P,P-bidentate ligand. Diastereotopic phosphorus atoms were observed in P-31 NMR upon addition of SnCl2 to the parent complex (1) due to the formation of [PtCl(PNP)][SnCl3] (2a). The formation of similar complex cations, [PtX(PNP)](+) (where X = I (4), CN (5)) containing PNP as a terdentate ligand was also observed when KI and KCN was added in the presence of SnCl2, which formed trichlorostannate counterion. The addition of PPh3 to 1 resulted in the partial formation of [Pt(PPh3)(PNP)](2+) (3), which could be accomplished upon addition of SnCl2. The catalytic activity of the platinum-PNP system in the hydroformylation of styrene is low. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(01)00384-x

文献信息

• Palladium-Catalyzed Cyclization of 6-Aminohex-1-yne
  作者：Thomas E. Müller、Michael Berger、Manja Grosche、Eberhardt Herdtweck、Franz P. Schmidtchen

  DOI：10.1021/om010524n

  日期：2001.10.1

  IR and NMR spectroscopy, were used to obtain evidence for a possible reaction cycle. It seems likely that (i) the substrate initially coordinates via the amine group and (ii) an intermediate is formed which is the product of a nucleophilic attack of the amine on a coordinated alkyne. Addition of an acid to the reaction mixture led to a strong increase in the reaction rate, probably by accelerating protolytic

  以6-氨基己-1-炔环合成2-甲基-1,2-脱氢哌啶为例，研究了钯催化炔烃加成胺的机理和限制因素。络合物[Pd（Triphos）]（CF 3 SO 3）2在一系列结构上和电子上不同的钯配合物中，具有最高的催化活性。几种方法，例如量热法和原位红外光谱和核磁共振光谱法，被用来获得可能的反应周期的证据。似乎（i）底物最初通过胺基团进行配位，并且（ii）形成了中间体，该中间体是胺对配位炔的亲核攻击的产物。向反应混合物中添加酸可导致反应速率显着提高，这可能是通过加速中间体复合物中钯-碳键的蛋白水解裂解来实现的。
• Platinum complexes of (R)-N,N-bis(2-(diphenylphosphino)ethyl)-1-phenyl-ethylamine: their synthesis and characterisation
  作者：László Jánosi、Tamás Kégl、László Hajba、Zoltán Berente、László Kollár

  DOI：10.1016/s0020-1693(01)00384-x

  日期：2001.5

  Both neutral and ionic platinum complexes of (R)-N,N-bis-(2-diphenylpho sphinoethyl)-1-phenyl-ethylamine (PNP) were synthesised. In the reaction of PtCl2(PhCN)(2) and PNP cis-PtCl2(eta (2)-P,P-PNP) (1) was formed coordinating PNP as a P,P-bidentate ligand. Diastereotopic phosphorus atoms were observed in P-31 NMR upon addition of SnCl2 to the parent complex (1) due to the formation of [PtCl(PNP)][SnCl3] (2a). The formation of similar complex cations, [PtX(PNP)](+) (where X = I (4), CN (5)) containing PNP as a terdentate ligand was also observed when KI and KCN was added in the presence of SnCl2, which formed trichlorostannate counterion. The addition of PPh3 to 1 resulted in the partial formation of [Pt(PPh3)(PNP)](2+) (3), which could be accomplished upon addition of SnCl2. The catalytic activity of the platinum-PNP system in the hydroformylation of styrene is low. (C) 2001 Elsevier Science B.V. All rights reserved.