2-Amino-1-acetoxy-cyclohexan | 98552-56-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Amino-1-acetoxy-cyclohexan
• 英文别名: (2-Aminocyclohexyl) acetate
• CAS: 98552-56-8
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: NZWMVSIGTQJHHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  trans-1-(N-acetylamino)-2-bromocyclohexane 在 水 作用下， 以 甲醇 为溶剂， 生成 2-Amino-1-acetoxy-cyclohexan
  参考文献：
  名称：

  Beger,J. et al., Journal fur praktische Chemie (Leipzig 1954), 1969, vol. 311, p. 15 - 35

  摘要：

  DOI：

文献信息

• [EN] IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF FOR TREATMENT OF OBESITY<br/>[FR] PREPARATION ET UTILISATION DE DERIVES D'IMIDAZOLE DANS LE TRAITEMENT DE L'OBESITE
  申请人：BAYER PHARMACEUTICALS CORPORAT

  公开号：WO2003040107A1

  公开（公告）日：2003-05-15

  This invention relates to substituted imidazole derivatives of formula I, which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

  本发明涉及公式I的取代咪唑衍生物，已发现其抑制食欲和诱导减重的作用。本发明还提供了合成该化合物的方法、包含该化合物的药物组合物，以及使用这些组合物诱导减重和治疗肥胖和肥胖相关疾病的方法。
• Capsaicinoid prodrug compounds and their use in treating medical conditions
  申请人：Centrexion Therapeutics Corporation

  公开号：US11254659B1

  公开（公告）日：2022-02-22

  The invention provides capsaicinoid prodrug compounds (e.g., prodrugs of resiniferatoxin, tinyatoxin, iodoresiniferatoxin, and related compounds), pharmaceutical compositions, and their use in the treatment of medical conditions, such as pain, and in agonizing TRPV1 activity.

  本发明提供了辣椒素原药化合物（例如，松脂铁毒素、微小铁毒素、碘松脂铁毒素和相关化合物的原药）、药物组合物，以及它们在治疗疼痛等病症和激动TRPV1活性方面的用途。
• IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF FOR TREATMENT OF OBESITY
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP1432691A1

  公开（公告）日：2004-06-30
• PROCESS FOR THE PREPARATION OF AN ENANTIOMERICALLY AND/OR DIASTEREOMERICALLY ENRICHED ESTER, THIOESTER, ALCOHOL OR THIOL
  申请人：DSM IP Assets B.V.

  公开号：EP2203562A1

  公开（公告）日：2010-07-07
• [EN] PROCESS FOR THE PREPARATION OF AN ENANTIOMERICALLY AND/OR DIASTEREOMERICALLY ENRICHED ESTER, THIOESTER, ALCOHOL OR THIOL<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN ESTER, THIOESTER, ALCOOL OU THIOL ÉNANTIOMÉRIQUEMENT ET/OU DIASTÉRÉOMÉRIQUEMENT ENRICHI
  申请人：DSM IP ASSETS BV

  公开号：WO2009050216A1

  公开（公告）日：2009-04-23

  The invention relates to a process for preparing an enantiomerically and/or diastereomerically enriched ester or thioester having at least two adjacent chiral centres, wherein a mixture of stereoisomers of a secondary alcohol or thiol having a structure comprising a first chiral center forming a secondary alcohol or secondary thiol moiety in the beta position relative to a second chiral center having one hydrogen substituent, is reacted with an acyl donor in the presence of an epimerisation catalyst and a stereoselective acylation catalyst.