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(4-Dimethylamino-[1]naphthyl)-(4-dimethylamino-phenyl)-methanol | 40300-95-6

中文名称
——
中文别名
——
英文名称
(4-Dimethylamino-[1]naphthyl)-(4-dimethylamino-phenyl)-methanol
英文别名
[4-(Dimethylamino)naphthalen-1-yl]-[4-(dimethylamino)phenyl]methanol
(4-Dimethylamino-[1]naphthyl)-(4-dimethylamino-phenyl)-methanol化学式
CAS
40300-95-6
化学式
C21H24N2O
mdl
——
分子量
320.434
InChiKey
LGKIMNPFMICWLF-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.2
  • 重原子数:
    24
  • 可旋转键数:
    4
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.24
  • 拓扑面积:
    26.7
  • 氢给体数:
    1
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay
    作者:Songchun Jiang、Candace Crogan-Grundy、John Drewe、Ben Tseng、Sui Xiong Cai
    DOI:10.1016/j.bmcl.2008.09.088
    日期:2008.11
    We report the discovery of a series of (naphthalen-4-yl)(phenyl)methanones as potent inducers of apoptosis using our proprietary cell- and caspase-based ASAP HTS assay. Through SAR studies, a group of N-methyl-N-phenylnaphthalen-1-amines also were identified as potent inducers of apoptosis. (1-(Dimethylamino) naphthalen-4-yl)(4-(dimethylamino)phenyl)methanone (2a), one of the most potent analogs, had EC(50) values of 37, 49 and 44 nM in T47D, HCT116 and SNU398 cells, respectively. Compound 2a also was highly active in a growth inhibition assay with an GI(50) value of 34 nM in T47D cells. Functionally, compound 2a arrested HCT116 cells in G(2)/M followed by induction of apoptosis and inhibited tubulin polymerization. (C) 2008 Elsevier Ltd. All rights reserved.
  • XVIII.—Studies in the naphthalene series. Part II. Diaryl- and triaryl-methane derivatives of methyl-α-naphthylamine
    作者:Basker Gokhle、Frederick Alfred Mason
    DOI:10.1039/jr9310000118
    日期:——
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