1-[(3-oxo-4H-quinoxalin-2-yl)amino]-3-phenylurea | 126802-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-[(3-oxo-4H-quinoxalin-2-yl)amino]-3-phenylurea
• CAS: 126802-29-7
• 化学式: C₁₅H₁₃N₅O₂
• 分子量: 295.301
• InChiKey: PCSYJIJJJRDGKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.07
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.91
• 氢给体数：
  4.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1,4-二氢-2,3-喹喔啉二酮单腙 、 苯甲酰基叠氮化物 生成 1-[(3-oxo-4H-quinoxalin-2-yl)amino]-3-phenylurea
  参考文献：
  名称：

  Reddy Sastry; Marwah; Marwah, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 10, p. 885 - 887

  摘要：

  DOI：

文献信息

• Transition metal complexes of thiosemicarbazones with quinoxaline hub: an emphasis on antidiabetic property
  作者：Naveen V. Kulkarni、Vidyanand K. Revankar、B. N. Kirasur、Mallinath H. Hugar

  DOI：10.1007/s00044-011-9576-6

  日期：2012.5

  New transition metal complexes of quinoxaline-thiosemicarbazone ligands were prepared and characterised by spectroanalytical techniques. The ligands L H-1(2) and L H-2(2) were obtained by the reaction of quinoxaline-2.3(1,4H)-dione with methyl and phenyl thiosemicarbazide, respectively. All the complexes are found to be monomeric in nature and have tetrahedral geometry. The copper complexes have shown redox responses in the applied voltage range, whereas the ligands and other complexes are electrochemically innocent. The ligands, copper and zinc complexes are explored for antidiabetic activity in the diabetes-induced Wister rats. Evaluation of antidiabetic activity was done by blood-glucose test and oral glucose tolerance test; few compounds have exhibited significant antidiabetic activity and posses low toxicity with a high safety profile.
• SASTRY, C. V. REDDY;MARWAH, P.;MARWAH, A. K.;RAO, G. SHANKAR, INDIAN J. CHEM. B, 28,(1989) N0, C. 885-887
  作者：SASTRY, C. V. REDDY、MARWAH, P.、MARWAH, A. K.、RAO, G. SHANKAR

  DOI：——

  日期：——