(9ci)-2-氟-7-甲氧基萘 | 62078-77-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: (9ci)-2-氟-7-甲氧基萘
• 英文名称: 2-fluoro-7-methoxynaphthalene
• 英文别名: 7-Fluor-2-methoxynaphthalin；7-fluoro-2-methoxy-naphthalene
• CAS: 62078-77-7
• 化学式: C₁₁H₉FO
• 分子量: 176.19
• InChiKey: RTTJMNBBXILASL-UHFFFAOYSA-N

物化性质

• 沸点：
  272.3±13.0 °C(Predicted)
• 密度：
  1.160±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  (9ci)-2-氟-7-甲氧基萘 在 三溴化磷 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以85%的产率得到7-氟萘-2-醇
  参考文献：
  名称：

  Deleterious effect of 7-methyl group on glycosylation of 2-naphthols

  摘要：

  C-Glycosylations of several 2-naphthols with different glycosyl donors have been investigated in the pursuit of the total synthesis of mayamycin (I). While glycosylations of the parent 2-naphthol are readily achievable, those of 5-methoxy-7-methyl-2-naphthol (6) embodying the target are ineffective under different Lewis acidic conditions. The inefficiency of the glycosylation of 6 has been attributed to the steric effect exerted by C7 methyl group, which was corroborated by glycosylation studies of different 2-naphthols. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.06.045
• 作为产物：
  描述：

  2-fluoro-7-methoxy-3,4-dihydronaphthalen-1(2H)-one 在 吡啶 、 sodium tetrahydroborate 、 对甲苯磺酸 作用下， 以 甲醇 、 苯 为溶剂， 反应 12.0h， 生成 (9ci)-2-氟-7-甲氧基萘
  参考文献：
  名称：

  Deleterious effect of 7-methyl group on glycosylation of 2-naphthols

  摘要：

  C-Glycosylations of several 2-naphthols with different glycosyl donors have been investigated in the pursuit of the total synthesis of mayamycin (I). While glycosylations of the parent 2-naphthol are readily achievable, those of 5-methoxy-7-methyl-2-naphthol (6) embodying the target are ineffective under different Lewis acidic conditions. The inefficiency of the glycosylation of 6 has been attributed to the steric effect exerted by C7 methyl group, which was corroborated by glycosylation studies of different 2-naphthols. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.06.045

文献信息

• Deleterious effect of 7-methyl group on glycosylation of 2-naphthols
  作者：Prithiba Mitra、Subhajit Mandal、Soumen Chakraborty、Dipakranjan Mal

  DOI：10.1016/j.tet.2015.06.045

  日期：2015.8

  C-Glycosylations of several 2-naphthols with different glycosyl donors have been investigated in the pursuit of the total synthesis of mayamycin (I). While glycosylations of the parent 2-naphthol are readily achievable, those of 5-methoxy-7-methyl-2-naphthol (6) embodying the target are ineffective under different Lewis acidic conditions. The inefficiency of the glycosylation of 6 has been attributed to the steric effect exerted by C7 methyl group, which was corroborated by glycosylation studies of different 2-naphthols. (C) 2015 Elsevier Ltd. All rights reserved.

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