(1S,3S,5S)-2-[(2S)-2-amino-2-(1-naphthalen-1-ylsulfonylpiperidin-4-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile | 1426946-21-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (1S,3S,5S)-2-[(2S)-2-amino-2-(1-naphthalen-1-ylsulfonylpiperidin-4-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• CAS: 1426946-21-5
• 化学式: C₂₃H₂₆N₄O₃S
• 分子量: 438.55
• InChiKey: LEAQSGFGYZSYEM-RQIDZSJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (1S,3S,5S)-2-((2-nitrophenyl)thio)-2-azabicyclo[3.1.0]hexane-3-carboxamide 在 吡啶 、 咪唑 、 盐酸 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 、 三氯氧磷 作用下， 以 1,4-二氧六环 、 乙醚 、 二氯甲烷 、 水 为溶剂， 生成 (1S,3S,5S)-2-[(2S)-2-amino-2-(1-naphthalen-1-ylsulfonylpiperidin-4-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
  参考文献：
  名称：

  Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors

  摘要：

  Synthesis and structure-activity relationship of a series of substituted piperidinyl glycine 2-cyano-4,5-methano pyrroline DPP-IV inhibitors are described. Improvement of the inhibitory activity and chemical stability of this series of compounds was respectively achieved by the introduction of bulky groups at the 4-position and 1-position of the piperidinyl glycine, leading to a series of potent and stable DPP-IV inhibitors. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.104

文献信息

• Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors
  作者：Guohua Zhao、Chet Kwon、Aiying Wang、James G. Robertson、Jovita Marcinkeviciene、Rex A. Parker、Mark S. Kirby、Lawrence G. Hamann

  DOI：10.1016/j.bmcl.2013.01.104

  日期：2013.3

  Synthesis and structure-activity relationship of a series of substituted piperidinyl glycine 2-cyano-4,5-methano pyrroline DPP-IV inhibitors are described. Improvement of the inhibitory activity and chemical stability of this series of compounds was respectively achieved by the introduction of bulky groups at the 4-position and 1-position of the piperidinyl glycine, leading to a series of potent and stable DPP-IV inhibitors. (C) 2013 Elsevier Ltd. All rights reserved.