salicylaldehydemethanesulfonylhydrazone | 263009-12-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: salicylaldehydemethanesulfonylhydrazone
• 英文别名: N-[(2-hydroxyphenyl)methylideneamino]methanesulfonamide
• CAS: 263009-12-7
• 化学式: C₈H₁₀N₂O₃S
• 分子量: 214.245
• InChiKey: AQOAHEKGBGYIRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  salicylaldehydemethanesulfonylhydrazone 、 palladium dichloride 在 sodium hydroxide 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 1.0h， 以50%的产率得到[Pd(salmsh)2]
  参考文献：
  名称：

  New nickel(II), palladium(II), platinum(II) complexes with aromatic methanesulfonylhydrazone based ligands. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation

  摘要：

  Methanesulfonicacid hydrazide (a sulfonamide compound, msh: CH3SO2NHNH2) derivatives: salicylalde hydemethanesulfonylhydrazone (salmsh), 2-hydroxyacetophenonemethanesulfonyl hydrazone (afmsh), 2-hydroxy-3-metoxybenzaldehydemethanesulfonylhydrazone (o-vanmsh) and their Ni(II), Pd(II) and Pt (II) complexes have been synthesized. The structure of these compounds has been investigated by using elemental analyses; FT-IR, H-1 NMR, LC-MS, UV-Visible spectrometric methods; magnetic susceptibility; conductivity measurements; thermal studies. The antibacterial activities of synthesized compounds have been determined in vitro against gram positive bacteria; Staphylococcus aureus ATCC 25923, Bacillus cereus RSKK 709, and gram negative bacteria; Pseudomonos aeruginosa ATCC 27853, Escherichia coli ATCC 35268 by paper disc diffusion and microdilution broth methods. The biological activity screening showed that metal complexes have more activity than their ligands against the tested bacteria. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.01.031
• 作为产物：
  描述：

  甲磺酰肼 、 水杨醛 以 乙醇 为溶剂， 反应 3.0h， 以50%的产率得到salicylaldehydemethanesulfonylhydrazone
  参考文献：
  名称：

  New nickel(II), palladium(II), platinum(II) complexes with aromatic methanesulfonylhydrazone based ligands. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation

  摘要：

  Methanesulfonicacid hydrazide (a sulfonamide compound, msh: CH3SO2NHNH2) derivatives: salicylalde hydemethanesulfonylhydrazone (salmsh), 2-hydroxyacetophenonemethanesulfonyl hydrazone (afmsh), 2-hydroxy-3-metoxybenzaldehydemethanesulfonylhydrazone (o-vanmsh) and their Ni(II), Pd(II) and Pt (II) complexes have been synthesized. The structure of these compounds has been investigated by using elemental analyses; FT-IR, H-1 NMR, LC-MS, UV-Visible spectrometric methods; magnetic susceptibility; conductivity measurements; thermal studies. The antibacterial activities of synthesized compounds have been determined in vitro against gram positive bacteria; Staphylococcus aureus ATCC 25923, Bacillus cereus RSKK 709, and gram negative bacteria; Pseudomonos aeruginosa ATCC 27853, Escherichia coli ATCC 35268 by paper disc diffusion and microdilution broth methods. The biological activity screening showed that metal complexes have more activity than their ligands against the tested bacteria. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.01.031

文献信息

• New nickel(II), palladium(II), platinum(II) complexes with aromatic methanesulfonylhydrazone based ligands. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation
  作者：Ümmühan Ö. Özdemir、Nesrin Akkaya、Neslihan Özbek

  DOI：10.1016/j.ica.2013.01.031

  日期：2013.5

  Methanesulfonicacid hydrazide (a sulfonamide compound, msh: CH3SO2NHNH2) derivatives: salicylalde hydemethanesulfonylhydrazone (salmsh), 2-hydroxyacetophenonemethanesulfonyl hydrazone (afmsh), 2-hydroxy-3-metoxybenzaldehydemethanesulfonylhydrazone (o-vanmsh) and their Ni(II), Pd(II) and Pt (II) complexes have been synthesized. The structure of these compounds has been investigated by using elemental analyses; FT-IR, H-1 NMR, LC-MS, UV-Visible spectrometric methods; magnetic susceptibility; conductivity measurements; thermal studies. The antibacterial activities of synthesized compounds have been determined in vitro against gram positive bacteria; Staphylococcus aureus ATCC 25923, Bacillus cereus RSKK 709, and gram negative bacteria; Pseudomonos aeruginosa ATCC 27853, Escherichia coli ATCC 35268 by paper disc diffusion and microdilution broth methods. The biological activity screening showed that metal complexes have more activity than their ligands against the tested bacteria. (C) 2013 Elsevier B.V. All rights reserved.