methyl-[5-(naphth-1-yloxy)pentyl]amine | 361395-31-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl-[5-(naphth-1-yloxy)pentyl]amine
• 英文别名: N-methyl-5-naphthalen-1-yloxypentan-1-amine
• CAS: 361395-31-5
• 化学式: C₁₆H₂₁NO
• mdl: MFCD17081967
• 分子量: 243.349
• InChiKey: OKTHWSZPNZAXGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5,6,7-四氢-1H-苯并咪唑-5-甲酸 、 methyl-[5-(naphth-1-yloxy)pentyl]amine 生成 4,5,6,7-Tetrahydro-1 H-benzimidazole-5-carboxylic acid methyl-[5-(naphth-1-yloxy)pentyl]amide, Hydrochloride
  参考文献：
  名称：

  Imidazole compounds

  摘要：

  一种新型的咪唑杂环化合物类，包括它们的药物组合物以及在治疗和/或预防与组织胺H3受体相关的疾病和疾病的用途。更具体地说，这些化合物对于治疗和/或预防与组织胺H3受体相互作用有益的疾病和疾病是有用的。

  公开号：

  US20020058659A1
• 作为产物：
  描述：

  萘酚 在 sodium hydride 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 methyl-[5-(naphth-1-yloxy)pentyl]amine
  参考文献：
  名称：

  Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake

  摘要：

  A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta(TM)) has proven to be effective in clinical trials for the treatment of depression. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.08.079

文献信息

• CONDENSED IMIDAZOLES AS HISTAMINE H3 RECEPTOR LIGANDS
  申请人：NOVO NORDISK A/S

  公开号：EP1268484A1

  公开（公告）日：2003-01-02
• US6437147B1
  申请人：——

  公开号：US6437147B1

  公开（公告）日：2002-08-20
• US6756384B2
  申请人：——

  公开号：US6756384B2

  公开（公告）日：2004-06-29
• [EN] CONDENSED IMIDAZOLES AS HISTAMINE H3 RECEPTOR LIGANDS<br/>[FR] IMIDAZOLES CONDENSES EN TANT QUE LIGANDS DE RECEPTEUR D'HISTAMINE H3
  申请人：NOVO NORDISK AS

  公开号：WO2001068652A1

  公开（公告）日：2001-09-20

  A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
• Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake
  作者：F.P. Bymaster、E.E. Beedle、J. Findlay、P.T. Gallagher、J.H. Krushinski、S. Mitchell、D.W. Robertson、D.C. Thompson、L. Wallace、D.T. Wong

  DOI：10.1016/j.bmcl.2003.08.079

  日期：2003.12

  A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta(TM)) has proven to be effective in clinical trials for the treatment of depression. (C) 2003 Elsevier Ltd. All rights reserved.