5-(1,2-Diphenylethyl)-barbituric acid | 109317-84-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 5-(1,2-Diphenylethyl)-barbituric acid
• 英文别名: 5-(1,2-Diphenylethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione；5-(1,2-diphenylethyl)-1,3-diazinane-2,4,6-trione
• CAS: 109317-84-2
• 化学式: C₁₈H₁₆N₂O₃
• 分子量: 308.337
• InChiKey: DDYYUVJVLQNQKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(1,2-Diphenylethyl)-barbituric acid 在 五氯化磷 、 三氯氧磷 作用下， 生成 5-(1,2-diphenylethyl)-2,4,6-trichloropyrimidine
  参考文献：
  名称：

  Synthesis and antibacterial activity of 2-substituted 5-(1,2-diarylethyl)-4,6-dichloropyrimidine derivatives

  摘要：

  A series of 5-(1,2-diarylethyl)-2,4,6-trichloropyrimidines and 2-amino- and 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human bacterial flora. Biological tests showed that 5-[1-(4-chlorophenyl)-2-phenylethyl]-2,4,6-trichloropyrimidine is very active against a wide range of bacterial flora of the axilla and foot, while 2-amino and 2-(1-piperazinyl)-4,6- dichloropyrimidine derivatives display a great selectivity against Corynebacterium xerosis and Arcanobacterium haemolyticum of the human axilla.

  DOI：

  10.1016/0223-5234(96)88279-1
• 作为产物：
  描述：

  苯甲醛 、 alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 以 水 为溶剂， 反应 1.0h， 生成 5-(1,2-Diphenylethyl)-barbituric acid
  参考文献：
  名称：

  Synthesis and antibacterial activity of 2-substituted 5-(1,2-diarylethyl)-4,6-dichloropyrimidine derivatives

  摘要：

  A series of 5-(1,2-diarylethyl)-2,4,6-trichloropyrimidines and 2-amino- and 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human bacterial flora. Biological tests showed that 5-[1-(4-chlorophenyl)-2-phenylethyl]-2,4,6-trichloropyrimidine is very active against a wide range of bacterial flora of the axilla and foot, while 2-amino and 2-(1-piperazinyl)-4,6- dichloropyrimidine derivatives display a great selectivity against Corynebacterium xerosis and Arcanobacterium haemolyticum of the human axilla.

  DOI：

  10.1016/0223-5234(96)88279-1

文献信息

• Synthesis of Substituted Barbituric Acids<i>via</i>Organozinc Reagents
  作者：Y. Frangin、C. Guimbal、F. Wissocq、H. Zamarlik

  DOI：10.1055/s-1986-31870

  日期：——

  5-(1,2-Diarylethyl)- and 5-(1-aryl-3-butenyl)-barbituric acids are prepared in good yields from, 5-benzylidenebarbituric acids and benzylzinc bromide or allylzinc bromide, respectively. The products are used as starting materials for the synthesis of the correspondingly 5-substituted 1,3,5-triallyl-, 1,3,5-tris [2-propynyl]-, and 5-hydroxybarbituric acid derivatives.

  5-(1,2-二叔丁基)-和 5-(1-芳基-3-丁烯基)-巴比妥酸分别由 5-亚苄基巴比妥酸和苄基溴化锌或烯丙基溴化锌以良好的收率制备而成。 这些产物可用作合成相应的 5 取代 1,3,5-三烯丙基、1,3,5-三[2-丙炔基]和 5-羟基巴比妥酸衍生物的起始原料。
• FRANGIN Y.; GUIMBAL C.; WISSOCQ F.; ZAMARLIK H., SYNTHESIS,(1986) N 12, 1046-1050
  作者：FRANGIN Y.、 GUIMBAL C.、 WISSOCQ F.、 ZAMARLIK H.

  DOI：——

  日期：——
• Synthesis and antibacterial activity of 2-substituted 5-(1,2-diarylethyl)-4,6-dichloropyrimidine derivatives
  作者：Y Fellahi、P Dubois、D Mandin、JE Ombetta-Goka、J Guenzet、JP Chaumont、Y Frangin

  DOI：10.1016/0223-5234(96)88279-1

  日期：1995.1

  A series of 5-(1,2-diarylethyl)-2,4,6-trichloropyrimidines and 2-amino- and 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human bacterial flora. Biological tests showed that 5-[1-(4-chlorophenyl)-2-phenylethyl]-2,4,6-trichloropyrimidine is very active against a wide range of bacterial flora of the axilla and foot, while 2-amino and 2-(1-piperazinyl)-4,6- dichloropyrimidine derivatives display a great selectivity against Corynebacterium xerosis and Arcanobacterium haemolyticum of the human axilla.