1-(Chloroacetamido)-5,6,7,8-tetrahydronaphthalin | 22302-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-(Chloroacetamido)-5,6,7,8-tetrahydronaphthalin
• 英文别名: chloro-acetic acid-(5,6,7,8-tetrahydro-[1]naphthylamide)；Chlor-essigsaeure-(5,6,7,8-tetrahydro-[1]naphthylamid)；2-chloro-N-(5,6,7,8-tetrahydronaphthyl)acetamide；5-chloroacetamino-1,2,3,4-tetrahydronaphthalene；2-chloro-N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide
• CAS: 22302-73-4
• 化学式: C₁₂H₁₄ClNO
• mdl: MFCD00995774
• 分子量: 223.702
• InChiKey: VEGAWTCJFWDVFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(Chloroacetamido)-5,6,7,8-tetrahydronaphthalin 生成 (3-tert-butyl-2-oxo-2λ⁴-[1,2,3]oxathiazolidin-5-ylidene)-(5,6,7,8-tetrahydro-naphthalen-1-yl)-amine
  参考文献：
  名称：

  Arya,V.P. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1977, vol. 15, p. 133 - 140

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氨基四氢化萘 以 乙醚 为溶剂， 生成 1-(Chloroacetamido)-5,6,7,8-tetrahydronaphthalin
  参考文献：
  名称：

  Method of selective weed control with certain chloroacetamides

  摘要：

  植物生长调节剂，该剂含有至少一种式为##SPC1##的酰胺类活性物质，其中R.sub.1代表氢、甲基或乙基，R.sub.2代表氢、甲基、乙基、正丙基、异丙基、甲氧基乙基、烯丙氧甲基或较低的烷氧甲基，n表示数字3或4。

  公开号：

  US03936293A1

文献信息

• [EN] PESTICIDAL COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PESTICIDES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2020163146A1

  公开（公告）日：2020-08-13

  This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the structure of Formula A.

  这项披露涉及具有杀虫用途的分子领域，用于对线虫门、节肢动物门和/或软体动物门的害虫具有杀虫效用的分子，用于生产此类分子的过程和用于此类过程的中间体，含有此类分子的组合物，以及使用此类分子对抗此类害虫的过程。这些分子可以用作线虫杀剂、螨虫杀剂、杀虫剂、螨虫剂和/或软体动物杀剂。本文件披露了具有A式结构的分子。
• Substituted heterocyclic compounds
  申请人：——

  公开号：US20040152890A1

  公开（公告）日：2004-08-05

  Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

  本发明涉及新型杂环衍生物，可用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常、间歇性跛行、普林兹梅特尔（变异型）心绞痛、稳定和不稳定性心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗塞。该化合物也可用于糖尿病的治疗。
• Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1806346A1

  公开（公告）日：2007-07-11

  Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

  所公开的新型杂环衍生物可用于治疗各种疾病，尤其是心血管疾病，如房性和室性心律失常、间歇性跛行、普林兹梅塔尔（变异型）心绞痛、稳定型和不稳定型心绞痛、运动诱发心绞痛、充血性心脏病和心肌梗塞。这些化合物还可用于治疗糖尿病。
• Pesticidal compositions and methods
  申请人：CORTEVA AGRISCIENCE LLC

  公开号：US11332452B2

  公开（公告）日：2022-05-17

  This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the structure of Formula A.

  本公开涉及对线虫纲、节肢动物纲和/或软体动物纲害虫具有杀虫作用的分子、生产此类分子的工艺和用于此类工艺的中间体、含有此类分子的组合物以及使用此类分子对付此类害虫的工艺。例如，这些分子可用作杀线虫剂、杀螨剂、杀虫剂、杀螨剂和/或杀软体动物剂。本文公开了具有式 A 结构的分子。
• New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties
  作者：Dmitry O. Koltun、Timothy A. Marquart、Kevin D. Shenk、Elfatih Elzein、Yuan Li、Marie Nguyen、Suresh Kerwar、Dewan Zeng、Nancy Chu、Daniel Soohoo、Jia Hao、Victoria Y. Maydanik、David A. Lustig、Khing-Jow Ng、Heather Fraser、Jeffery A. Zablocki

  DOI：10.1016/j.bmcl.2003.09.093

  日期：2004.1

  New inhibitors of palmitoylCoA oxidation were synthesized based on a structurally novel lead, CVT-3501 (1). Investigation of structure-activity relationships was conducted with respect to potency of inhibition of cardiac mitochondrial palmitoylCoA oxidation and metabolic stability. Potent and metabolically stable analogues 33, 42, and 43 were evaluated in vitro for cytochrome P450 inhibition and potentially adverse electrophysiological effects. Compound 33 was also found to have favorable pharmacokinetic properties in rat. (C) 2003 Elsevier Ltd. All rights reserved.