2-isobutanoyl indene | 132638-42-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 2-isobutanoyl indene
• 英文别名: 1-(1H-inden-2-yl)-2-methylpropan-1-one
• CAS: 132638-42-7
• 化学式: C₁₃H₁₄O
• 分子量: 186.254
• InChiKey: AXFOHEXOHJAEKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(1H-Inden-2-yl)-2-methyl-propan-1-ol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 以72%的产率得到2-isobutanoyl indene
  参考文献：
  名称：

  Kher, S.M.; Kulkarni, G.H., Synthetic Communications, 1990, vol. 20, # 17, p. 2573 - 2578

  摘要：

  DOI：

文献信息

• Studies on the Synthesis of 2-Acyl-1H-Indenes via One-Pot Palladium-Catalysed Tandem Heck–Aldol Reaction
  作者：Song Tu、Yong Sha、Long-he Xu、Zong-yuan Xiao、Li-yi Ye、Jun Fang

  DOI：10.3184/030823410x12731659649772

  日期：2010.5

  2-Acyl-1H-indenes were synthesised efficiently by the reaction of o-halogenatedbenzaldehydes (or aryl ketones) with prop-2-en-1-ols via one-pot palladium-catalysed tandem Heck–aldol reaction in moderate to good yields. The optimal reaction conditions have been investigated and it was found that sodium acetate was the most effective base and in addition tetrabutylammonium chloride and LiCl was crucial for this process. Moreover, it was found that o-halogenatedbenzaldehydes react with various substituted prop-2-en-1-ols smoothly to produce the title compounds while 2-bromoacetophenone only reacted with 2-propen-1-ol to give the desired product.

  通过钯催化的一锅串联赫克-醛醇反应，邻卤代苯甲醛（或芳基酮）与丙-2-烯-1-醇的反应高效合成了 2-酰基-1H-茚，收率中等至良好。研究人员对最佳反应条件进行了研究，发现醋酸钠是最有效的碱，此外四丁基氯化铵和氯化锂对这一过程也至关重要。此外，研究还发现邻卤代苯甲醛能与各种取代的 2-丙烯-1-醇顺利反应，生成标题化合物，而 2-溴苯乙酮只能与 2-丙烯-1-醇反应，生成所需的产物。
• AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS
  申请人：RODGERS James D.

  公开号：US20120077798A1

  公开（公告）日：2012-03-29

  The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

  本发明涉及氮杂环丙烷和环丁烷衍生物，以及它们的组合物，使用方法和制备方法，它们是JAK抑制剂，可用于治疗JAK相关疾病，包括炎症和自身免疫性疾病，以及癌症。
• Methods and Compositions Using Cholinesterase Inhibitors
  申请人：Ieni John

  公开号：US20090042939A1

  公开（公告）日：2009-02-12

  The invention provides methods for treating and/or preventing Alzheimer's disease, psychiatric illnesses, encephalitis, meningitis, fetal alcohol syndrome, Karsakoff's syndrome, anoxic brain injury, cardiopulmonary resuscitation injuries, diabetes, Sjogren's syndrome, mental retardation, developmental delay, menopause, strokes, macular degeneration, neuronal loss associated with macular degeneration, sleep disorders, severe Alzheimer's disease, jet lag, post-traumatic stress disorder, anxiety disorders, panic attacks, obsessive-compulsive disorder, amnesia, and other disorders by administering to a patient in need thereof at least one cholinesterase inhibitor. The invention also provides novel pharmaceutical compositions that can be administered to the eyes or to the nose of patients. In one embodiment, the cholinesterase inhibitor is donepezil, a stereoisomer thereof and/or a pharmaceutically acceptable salt thereof. In other embodiments, the cholinesterase inhibitor can be one or more of phenserine, tolserine, phenethylnorcymserine, ganstigmine, epastigmine, tacrine, physostigmine, pyridostigmine, neostigmine, rivastigmine, galantamine, citicoline, velnacrine, huperzine, metrifonate, heptastigmine, edrophonium, TAK-147, T-82, and upreazine.
• US8420629B2
  申请人：——

  公开号：US8420629B2

  公开（公告）日：2013-04-16
• Kher, S.M.; Kulkarni, G.H., Synthetic Communications, 1990, vol. 20, # 17, p. 2573 - 2578
  作者：Kher, S.M.、Kulkarni, G.H.

  DOI：——

  日期：——