4-cyclohexylmethyl-resorcinol | 856079-37-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-cyclohexylmethyl-resorcinol
• 英文别名: 2.4-Dioxy-1-hexahydrobenzyl-benzol；4-Hexahydrobenzyl-resorcin；2'.4'-Dioxy-1.2.3.4.5.6-hexahydro-diphenylmethan；4-Cyclohexylmethyl-resorcin；4-(Cyclohexylmethyl)benzene-1,3-diol
• CAS: 856079-37-3
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: LCKNYIVPNNXYBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-cyclohexylmethyl-resorcinol 在 三氯化铝 、 苯 作用下， 生成 4-(5-cyclohexylmethyl-2,4-dimethoxy-phenyl)-4-oxo-butyric acid
  参考文献：
  名称：

  Synthetic Choleretics. III. Resorcinol Derivatives¹

  摘要：

  DOI：

  10.1021/ja01106a015
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 amalgamated zinc 作用下， 生成 4-cyclohexylmethyl-resorcinol
  参考文献：
  名称：

  Talbot; Adams, Journal of the American Chemical Society, 1927, vol. 49, p. 2041

  摘要：

  DOI：

文献信息

• Novel resorcinol derivatives for skin
  申请人：Harichian Bijan

  公开号：US20060210498A1

  公开（公告）日：2006-09-21

  New 4-substituted resorcinol derivatives of general formula I and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening: Wherein X 1 and/or X 2 represents hydrogen (H), linear or branched, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, or acyl groups. Preferably, X 1 and/or X 2 represents hydrogen (H); linear or branched, saturated or unsaturated C 1 -C 12 alkyl or acyl groups; R 1 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group. Preferably, R 1 represents hydrogen (H) or a C 1 alkyl group (i.e, methyl group). More preferably, R 1 represents hydrogen; n represents 0, 1. When n=0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond. When n=1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.

  一种通式I和/或B的新的4-取代邻苯二酚衍生物，以及其合成方法、化妆品组合物和使用方法，特别用于皮肤美白：其中X1和/或X2表示氢（H）、线性或支链、饱和或不饱和的C1-C12烷基、烯基或酰基。优选地，X1和/或X2表示氢（H）；线性或支链、饱和或不饱和的C1-C12烷基或酰基；R1表示氢（H）、线性或支链、环状或非环状、饱和或不饱和的C1-C12烷基、烯基、环烷基或环烯基。更优选地，R1表示氢（H）或C1烷基（即甲基）。更具体地，R1表示氢；n表示0或1。当n=0时，环是一个环戊基，可以有一个来自O、N或S的杂原子和/或一个双键。当n=1时，环是一个环己基，可以有一个来自O、N或S的杂原子和/或一个双键；m表示1到6之间的整数。
• Novel Resorcinol Derivatives for Skin
  申请人：Harichian Bijan

  公开号：US20080131382A1

  公开（公告）日：2008-06-05

  New 4-substituted resorcinol derivatives of general formula I and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening: Wherein X 1 and/or X 2 represents hydrogen (H), linear or branched, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, or acyl groups. Preferably, X 1 and/or X 2 represents hydrogen (H); linear or branched, saturated or unsaturated C 1 -C 12 alkyl or acyl groups; R 1 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group. Preferably, R 1 represents hydrogen (H) or a C 1 alkyl group (i.e, methyl group). More preferably, R 1 represents hydrogen; n represents 0, 1. When n=0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond. When n=1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.

  新的4-取代邻苯二酚衍生物的一般式I和/或B以及其合成方法，化妆品组合物和使用它们的方法，特别是用于皮肤美白的方法： 其中X1和/或X2代表氢（H），线性或支链的，饱和或不饱和的C1-C12烷基，烯基或酰基。优选地，X1和/或X2代表氢（H）；线性或支链的，饱和或不饱和的C1-C12烷基或酰基；R1代表氢（H），线性或支链的，环状或非环状的，饱和或不饱和的C1-C12烷基，烯基，环烷基或环烯基。更优选地，R1代表氢（H）或C1烷基（即甲基基团）。更更优选地，R1代表氢；n代表0或1。当n=0时，环是一个环戊基，带或不带一个来自O、N或S的杂原子和/或一个双键。当n=1时，环是一个环己基，带或不带一个来自O、N或S的杂原子和/或一个双键；m代表1到6之间的整数。
• Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids
  申请人：Conopco, Inc.

  公开号：US11260005B2

  公开（公告）日：2022-03-01

  Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

  含氨基酸和4-取代的儿茶酚类化合物的外用个人护理组合物，用于增强皮肤细胞内的谷胱甘肽合成。这些组合物可用于改善因紫外线/阳光照射或环境污染物引起的皮肤外观，如与年龄相关的皮肤老化或光老化。这些组合物还有助于实现均匀的肤色、减少色素沉着、老年斑和色斑。
• Talbot; Adams, Journal of the American Chemical Society, 1927, vol. 49, p. 2401
  作者：Talbot、Adams

  DOI：——

  日期：——
• NOVEL RESORCINOL DERIVATIVES FOR SKIN
  申请人：Unilever PLC

  公开号：EP1861353B1

  公开（公告）日：2008-10-08