(1-DODECYLHEXAHYDRO-1H-氮杂卓-1-氧化物) | 56501-36-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (1-DODECYLHEXAHYDRO-1H-氮杂卓-1-氧化物)
• 英文名称: 1-dodecyl-hexahydro-azepine-1-oxide
• 英文别名: 1-Dodecyl-hexahydro-azepin-1-oxid；1H-Azepine, hexahydro-1-dodecyl-, 1-oxide；1-dodecyl-1-oxidoazepan-1-ium
• CAS: 56501-36-1
• 化学式: C₁₈H₃₇NO
• 分子量: 283.498
• InChiKey: HYDFMWOGHZZOKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1-DODECYLHEXAHYDRO-1H-氮杂卓-1-氧化物) 生成 N-Hydroxy-perhydroazepin
  参考文献：
  名称：

  DEVINSKY, FERDINAND;GORROD, JOHN W., J. CHROMATOGR., 466,(1989) C. 347-353

  摘要：

  DOI：
• 作为产物：
  描述：

  1-dodecyl-azepane 在 乙醇 、 双氧水 作用下， 生成 (1-DODECYLHEXAHYDRO-1H-氮杂卓-1-氧化物)
  参考文献：
  名称：

  Jerchel; Jung, Chemische Berichte, 1952, vol. 85, p. 1130,1136

  摘要：

  DOI：

文献信息

• Quinolyl-containing Hydroxamic Acid Compound and Preparation Method Thereof, and Pharmaceutical Composition Containing This Compound and Use Thereof
  申请人：Yun Ziwei

  公开号：US20140221425A1

  公开（公告）日：2014-08-07

  Provided in the present invention is a quinolyl-containing hydroxamic acid compound as shown in formula (I), at the same time also disclosed is the preparation method of the compound and the use thereof, and a pharmaceutical composition containing the quinolyl-containing hydroxamic acid compound. Such compounds are inhibitors of protein kinases and/or histone deacetylases, and can be used in the treatment of diseases caused by the abnormal activity of protein kinases and/or histone deacetylases, for example, tumors, etc.

  本发明提供了一种含有喹啉基羟肟酸化合物，如式（I）所示，同时还揭示了该化合物的制备方法及其用途，以及含有该含有喹啉基羟肟酸化合物的药物组合物。这些化合物是蛋白激酶和/或组蛋白去乙酰化酶的抑制剂，可用于治疗由蛋白激酶和/或组蛋白去乙酰化酶异常活动引起的疾病，例如肿瘤等。
• Skin penetration enhancing systems for polar drugs
  申请人：AmDerma Pharmaceuticals, LLC

  公开号：US10441530B2

  公开（公告）日：2019-10-15

  The invention relates to pharmaceutical compositions and related methods for the topical administration of polar drugs. In a particular embodiment, the invention relates to a pharmaceutical composition comprising an active pharmaceutical agent that is a polar drug, such as potassium 2,5-dihydroxybenzenesulfonate, at least one occlusive agent, and at least one stabilizer.

  本发明涉及极性药物局部用药的药物组合物和相关方法。在一个特定的实施方案中，本发明涉及一种药物组合物，其中包括一种极性药物的活性药剂，如 2,5-二羟基苯磺酸钾、至少一种闭塞剂和至少一种稳定剂。
• Topical application of muscarinic and opioid agents for treatment of tinnitus
  申请人：——

  公开号：US20020010191A1

  公开（公告）日：2002-01-24

  The present invention relates to a compositions and methods for treating tinnitus. In preferred embodiments of the invention, muscurinic and/or opioid agents are administered to the affected ear in amount effective to relieve one or more tinnitus symptoms. A preferred agent is an anticholinesterase inhibitor, such as neoostigmine.

  本发明涉及一种治疗耳鸣的组合物和方法。 在本发明的优选实施方案中，向受影响的耳部施用有效量的肌肉抑制剂和/或阿片类药物，以缓解一种或多种耳鸣症状。 一种优选的制剂是抗胆碱酯酶抑制剂，如新斯的明。
• Compositions and methods for treating female sexual response
  申请人：——

  公开号：US20020034557A1

  公开（公告）日：2002-03-21

  The present invention relates to compositions, articles of manufacture, methods of preparation thereof, methods of use thereof, etc., for enhancement of sexual pleasure, conditions, disorders, and diseases related to reproductive physiology and systems, especially of mammalian females. For instance, the present invention relates to all aspects of modulating the female sexual response, including female sexual dysfunction, such as female sexual arousal disorders (FSAD), orgasmic disorders, and sexual pain disorders, and enhancing female sexual pleasure and satisfaction of the female sexual experience. Accordingly, the present invention relates to compositions comprising botanical extracts, active agents, etc., which are useful to treat or affect any of the aforementioned conditions. For example, the present invention relates to a composition, preferably for topical or local use, which comprises one or more of the following ingredients, including, but not limited to, borage seed oil, Angelica pubescens root and other angelica species, Coleus forskohlii extract, vinpocetine, ferulic acid, magnesium, ascorbyl palmitate, capric/caprylic triglyceride, silica, and equivalents thereof.

  本发明涉及组合物、制造品、其制备方法、其使用方法等，用于提高性快感，改善与生殖生理和系统有关的状况、失调和疾病，特别是哺乳动物雌性的性快感。例如，本发明涉及调节女性性反应的各个方面，包括女性性功能障碍，如女性性唤起障碍（FSAD）、性高潮障碍和性疼痛障碍，以及提高女性性快感和女性性体验的满意度。因此，本发明涉及由植物提取物、活性剂等组成的组合物，这些组合物可用于治疗或影响上述任何病症。例如，本发明涉及一种组合物，优选用于局部或局部使用，其中包含一种或多种以下成分，包括但不限于琉璃苣籽油、 当归 根和其他当归品种、 鞘氨醇 提取物、长春花碱、阿魏酸、镁、抗坏血酸棕榈酸酯、癸/癸酸甘油三酯、二氧化硅及其等同物。
• DEVINSKY, FERDINAND;GORROD, JOHN W., J. CHROMATOGR., 466,(1989) C. 347-353
  作者：DEVINSKY, FERDINAND、GORROD, JOHN W.

  DOI：——

  日期：——