8-Bromomethyl-2,2,6-trimethyl-4H-benzo[1,3]dioxine | 206879-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 8-Bromomethyl-2,2,6-trimethyl-4H-benzo[1,3]dioxine
• 英文别名: 8-(bromomethyl)-2,2,6-trimethyl-4H-1,3-benzodioxine
• CAS: 206879-90-5
• 化学式: C₁₂H₁₅BrO₂
• 分子量: 271.154
• InChiKey: JGVRBGGVKFFDGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-Bromomethyl-2,2,6-trimethyl-4H-benzo[1,3]dioxine 在 高氯酸 、 水 、 sodium hydride 作用下， 以 氯仿 为溶剂， 反应 14.33h， 生成 7,15-Dimethyl-3,11,19-trioxatetracyclo[19.3.1.15,9.113,17]heptacosa-1(25),5(27),6,8,13,15,17(26),21,23-nonaene-25,26,27-triol
  参考文献：
  名称：

  Stepwise Construction of Some Hexahomooxacalix[3]arenes and Their Conformations in Solid State

  摘要：

  Hexahomooxacalix[3]arenes 1 bearing different substituents on their upper rim were synthesized from the corresponding Linear trimers 2 by the acid-catalyzed cyclization. The X-ray crystallographic analyses of 1 (R-1 = R-3 = H, R-2 = t-Bu, and R-1 = Et, R-2 = t-Bu, R-3 = i-Pr) revealed that they adopt a cone conformation, owing to an intramolecular hydrogen-bonded network in the solid state.

  DOI：

  10.1021/jo971945a
• 作为产物：
  描述：

  (2,2,6-trimethyl-4H-benzo[1,3]dioxin-8-yl)-methanol 在 溴 、 三苯基膦 作用下， 以60%的产率得到8-Bromomethyl-2,2,6-trimethyl-4H-benzo[1,3]dioxine
  参考文献：
  名称：

  Cyclohexa-2,4-dienone 和光化学反应中的分子内环加成：生成 Azatriquinane 和 Azasterpurane 骨架的有效途径

  摘要：

  描述了一种从简单的芳香族前体进入氮杂三喹烷和氮杂嘌呤骨架的新型、有效和立体选择性的入口。该方法涉及原位生成包含系链和分子内 π4s+π2s 环加成的环己-2,4-二烯酮，该环加成导致双环 [2.2.2] 辛烯酮成环的五元环含有氮。对所得加合物的进一步操作，随后进行光化学 sigmatropic 位移，很容易提供氮杂三喹烷和氮杂紫杉烷骨架。

  DOI：

  10.1055/s-2008-1072588

文献信息

• Intramolecular Cycloaddition in Cyclohexa-2,4-dienone and Photochemical Reactions: An Efficient Route to Azatriquinane and Azasterpurane Frameworks
  作者：Vishwakarma Singh、Bharat Sahu、Shaikh Mobin

  DOI：10.1055/s-2008-1072588

  日期：2008.5

  A novel, efficient and stereoselective entry to azatriquinane and azasterpurane frameworks from simple aromatic precursor, is described. The methodology involves in situ generation of cyclohexa-2,4-dienones containing a tether and intramolecular π4s+π2s cycloaddition that leads to a bicyclo[2.2.2]octenone-annulated five-membered ring that contains nitrogen. Further manipulation of the resulting adduct

  描述了一种从简单的芳香族前体进入氮杂三喹烷和氮杂嘌呤骨架的新型、有效和立体选择性的入口。该方法涉及原位生成包含系链和分子内 π4s+π2s 环加成的环己-2,4-二烯酮，该环加成导致双环 [2.2.2] 辛烯酮成环的五元环含有氮。对所得加合物的进一步操作，随后进行光化学 sigmatropic 位移，很容易提供氮杂三喹烷和氮杂紫杉烷骨架。
• RESIN COMPOSITION AND PATTERN FORMING METHOD USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20150118623A1

  公开（公告）日：2015-04-30

  A resin composition of the present invention includes a polymer compound (A) containing a repeating unit (Q) represented by the following general formula (1): wherein R 1 represents a hydrogen atom, a methyl group, or a halogen atom; R 2 and R 3 represent a hydrogen atom, an alkyl group, or a cycloalkyl group; L represents a divalent linking group or a single bond; Y represents a substituent excluding a methylol group; Z represents a hydrogen atom or a substituent; m represents an integer of 0 to 4; n represents an integer of 1 to 5; and m+n is 5 or less.
• US9718901B2
  申请人：——

  公开号：US9718901B2

  公开（公告）日：2017-08-01
• Stepwise Construction of Some Hexahomooxacalix[3]arenes and Their Conformations in Solid State
  作者：Kazunori Tsubaki、Tadamune Otsubo、Kiyoshi Tanaka、Kaoru Fuji、Takayoshi Kinoshita

  DOI：10.1021/jo971945a

  日期：1998.5.1

  Hexahomooxacalix[3]arenes 1 bearing different substituents on their upper rim were synthesized from the corresponding Linear trimers 2 by the acid-catalyzed cyclization. The X-ray crystallographic analyses of 1 (R-1 = R-3 = H, R-2 = t-Bu, and R-1 = Et, R-2 = t-Bu, R-3 = i-Pr) revealed that they adopt a cone conformation, owing to an intramolecular hydrogen-bonded network in the solid state.
• Singh, Vishwakarma; Sahu, Bharat C., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 8, p. 1148 - 1155
  作者：Singh, Vishwakarma、Sahu, Bharat C.

  DOI：——

  日期：——