1-(2'-methoxy-5'-methylphenyl)-2-naphthaleneacetic acid methyl ester | 135107-81-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2'-methoxy-5'-methylphenyl)-2-naphthaleneacetic acid methyl ester
• 英文别名: methyl 2-[1-(2-methoxy-5-methylphenyl)naphthalen-2-yl]acetate
• CAS: 135107-81-2
• 化学式: C₂₁H₂₀O₃
• 分子量: 320.388
• InChiKey: ZGUDPIAIRZVTKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.54
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-(2'-methoxy-5'-methylphenyl)-2-naphthaleneacetic acid methyl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 1-(2'-methoxy-5'-methylphenyl)-2-naphthaleneacetic acid
  参考文献：
  名称：

  Arylmagnesium bromide additions to 1-tetralone-2-acetic acid followed by catalytic hydrogenolysis: stereochemical consequences

  摘要：

  A Stork reaction route (7 --> 1b) was utilized to synthesize 1-tetralone-2-acetic acid methyl ester (1a) from 1-tetralone. Addition of a 2'-(o-methoxyphenyl) magnesium bromide to this ketone followed by palladium-catalyzed hydrogenation of the intermediate cis lactones (2, verified by X-ray crystal structure determination of 2a, Figure 1), afforded predominantly a 1,2-cis tetralin (3) accompanied by smaller yields of the corresponding 1,2-trans tetralin (4). The stereochemical consequences of this reaction sequence was unequivocally established by X-ray crystal structure elucidation of 1,2-cis methyl ester 3b (Figure 2) and 1,2-trans carboxylic acid 4a (Figure 3). Stereochemical assignments for the analogous diastereoisomeric sets 3c-f and 4c-f were obtained by high-field (400-MHz) H-1 and C-13 NMR correlations with the crystal structures. The overall reaction pathway illustrates a useful approach to 1,2-cis-alkylated tetralins and certain sterically hindered 1,2-trans-alkylated tetralins.

  DOI：

  10.1021/jo00018a030
• 作为产物：
  描述：

  cis 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid methyl ester 在 sulfur 、 zinc(II) chloride 作用下， 反应 0.33h， 以30%的产率得到1-(2'-methoxy-5'-methylphenyl)-2-naphthaleneacetic acid methyl ester
  参考文献：
  名称：

  Arylmagnesium bromide additions to 1-tetralone-2-acetic acid followed by catalytic hydrogenolysis: stereochemical consequences

  摘要：

  A Stork reaction route (7 --> 1b) was utilized to synthesize 1-tetralone-2-acetic acid methyl ester (1a) from 1-tetralone. Addition of a 2'-(o-methoxyphenyl) magnesium bromide to this ketone followed by palladium-catalyzed hydrogenation of the intermediate cis lactones (2, verified by X-ray crystal structure determination of 2a, Figure 1), afforded predominantly a 1,2-cis tetralin (3) accompanied by smaller yields of the corresponding 1,2-trans tetralin (4). The stereochemical consequences of this reaction sequence was unequivocally established by X-ray crystal structure elucidation of 1,2-cis methyl ester 3b (Figure 2) and 1,2-trans carboxylic acid 4a (Figure 3). Stereochemical assignments for the analogous diastereoisomeric sets 3c-f and 4c-f were obtained by high-field (400-MHz) H-1 and C-13 NMR correlations with the crystal structures. The overall reaction pathway illustrates a useful approach to 1,2-cis-alkylated tetralins and certain sterically hindered 1,2-trans-alkylated tetralins.

  DOI：

  10.1021/jo00018a030