8-acetoxy-2-methyl-[1,4]naphthoquinone | 149981-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-acetoxy-2-methyl-[1,4]naphthoquinone
• 英文别名: 8-Acetoxy-2-methyl-[1,4]naphthochinon；(7-Methyl-5,8-dioxonaphthalen-1-yl) acetate；(7-methyl-5,8-dioxonaphthalen-1-yl) acetate
• CAS: 149981-94-2
• 化学式: C₁₃H₁₀O₄
• 分子量: 230.22
• InChiKey: LUIAXILKRREHJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,8-Dimethoxy-7-methyl-1-naphthol 在 chromium(VI) oxide 、 sodium acetate 、 溶剂黄146 作用下， 生成 8-acetoxy-2-methyl-[1,4]naphthoquinone
  参考文献：
  名称：

  Asano; Hase, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1943, vol. 63, p. 83,88

  摘要：

  DOI：

文献信息

• Compositions and methods for treatment of prostate carcinoma
  申请人：Pellficure Pharmaceuticals, Inc.

  公开号：US10577315B2

  公开（公告）日：2020-03-03

  Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.

  本文公开了1,4-萘醌类似物、包括一种或多种此类1,4-萘醌类似物的药物组合物，以及用此类1,4-萘醌类似物治疗和/或改善与癌症（如前列腺癌）相关的疾病和/或病症的方法。还包括组合疗法，其中向患有癌症等疾病的受试者提供本文公开的 1,4-萘醌类似物和激素治疗剂。
• Synthesis of Plumbagin
  作者：L. F. Fieser、J. T. Dunn

  DOI：10.1021/ja01295a010

  日期：1936.4
• COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA
  申请人：Pellficure Pharmaceuticals, Inc.

  公开号：US20190169122A1

  公开（公告）日：2019-06-06

  Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.
• Asano; Hase, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1943, vol. 63, p. 83,88
  作者：Asano、Hase

  DOI：——

  日期：——